Mptx1 mucosal pentraxin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mptx1provided by RGD
Official Full Name: mucosal pentraxin 1provided by RGD
Primary source: RGD:1590926
See related: EnsemblRapid:ENSRNOG00000046165 AllianceGenome:RGD:1590926
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mptx
Summary: Predicted to enable complement component C1q complex binding activity. Predicted to be involved in innate immune response. Predicted to be active in extracellular space. Orthologous to human MPTX1 (mucosal pentraxin 1 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 8.1), Spleen (RPKM 2.8) and 2 other tissues See more
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Genomic context

Location:: 13q24

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (88260335..88263869, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (85727989..85731523, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (91772927..91827231, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrates that consideration of regional differences in Mptx gene expression and micro-anatomical location is necessary in the interpretation and deciphering of its regulation in colon.
Title: Complex regulation of mucosal pentraxin (Mptx) revealed by discrete micro-anatomical locations in colon.
Mptx expression is restricted to the intestine, related to colonic cell turnover, and that Mptx might be a marker for diet-modulated mucosal integrity
Title: Differential gene expression in rat colon by dietary heme and calcium.
Mucosal pentraxin (Mptx) is down-regulated in colon by dietary heme (Mptx).
Title: Mucosal pentraxin (Mptx), a novel rat gene 10-fold down-regulated in colon by dietary heme.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables complement component C1q complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mucosal pentraxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037642.2 → NP_001032731.1 mucosal pentraxin precursor

See identical proteins and their annotated locations for NP_001032731.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q6TA48

UniProtKB/TrEMBL

A6JG83

Related

ENSRNOP00000067540.1, ENSRNOT00000073147.3

Conserved Domains (1) summary

cd00152
Location:20 → 214

PTX; Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated ...