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    Gpn2 GPN-loop GTPase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362614, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpn2provided by RGD
    Official Full Name
    GPN-loop GTPase 2provided by RGD
    Primary source
    RGD:1311749
    See related
    EnsemblRapid:ENSRNOG00000007083 AllianceGenome:RGD:1311749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atpbd1b; RGD1311749
    Summary
    Predicted to enable GTPase activity. Orthologous to human GPN2 (GPN-loop GTPase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 69.2), Adrenal (RPKM 60.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpn2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (151093279..151101114)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (145809455..145817252)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (151806458..151813954)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL29-like Neighboring gene nuclear receptor subfamily 0, group B, member 2 Neighboring gene G patch domain containing 3 Neighboring gene zinc finger DHHC-type palmitoyltransferase 18 Neighboring gene stratifin Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    GPN-loop GTPase 2
    Names
    ATP-binding domain 1 family member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270959.1 → NP_001257888.1  GPN-loop GTPase 2

      See identical proteins and their annotated locations for NP_001257888.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      D4A7C0
      Related
      ENSRNOP00000009275.4, ENSRNOT00000009275.9
      Conserved Domains (2) summary
      COG1100
      Location:13 → 182
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam03029
      Location:14 → 261
      ATP_bind_1; Conserved hypothetical ATP binding protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      151093279..151101114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110392.2 → XP_038966320.1  GPN-loop GTPase 2 isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:27 → 148
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4A7C0.1 GenPept UniProtKB/Swiss-Prot:D4A7C0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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