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    Tom1l1 target of myb1 like 1 membrane trafficking protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287622, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tom1l1provided by RGD
    Official Full Name
    target of myb1 like 1 membrane trafficking proteinprovided by RGD
    Primary source
    RGD:1562626
    See related
    EnsemblRapid:ENSRNOG00000002474 AllianceGenome:RGD:1562626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Srcasm; RGD1562626
    Summary
    Predicted to enable clathrin binding activity; protein kinase activator activity; and protein kinase binding activity. Predicted to be involved in negative regulation of mitotic nuclear division; positive regulation of protein phosphorylation; and signal transduction. Predicted to be located in cytosol. Predicted to be active in endosome and membrane. Orthologous to human TOM1L1 (target of myb1 like 1 membrane trafficking protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 137.2), Liver (RPKM 107.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tom1l1 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (75961653..76005725, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (75464577..75508304, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (78173847..78219805, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480711 Neighboring gene syntaxin binding protein 4 Neighboring gene uncharacterized LOC134480712 Neighboring gene cytochrome c oxidase copper chaperone COX11 Neighboring gene target of myb1 like 3 membrane trafficking protein Neighboring gene transfer RNA alanine (anticodon AGC) 51 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TOM1L1 is a Lyn substrate involved in FcepsilonRI signaling in mast cells. Zhang J, et al. J Biol Chem, 2007 Dec 28. PMID 17977829
    2. Interactions of TOM1L1 with the multivesicular body sorting machinery. Puertollano R. J Biol Chem, 2005 Mar 11. PMID 15611048
    3. The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors. Franco M, et al. Mol Cell Biol, 2006 Mar. PMID 16479011, Free PMC Article
    4. Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. Katoh Y, et al. Biochem Biophys Res Commun, 2006 Mar 3. PMID 16412388
    5. 'Srcasm: a novel Src activating and signaling molecule. Seykora JT, et al. J Biol Chem, 2002 Jan 25. PMID 11711534

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TOM1-like protein 1
    Names
    Src-activating and signaling molecule protein
    Target of Myb-like protein 1
    target of myb1-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253859.1 → NP_001240788.1  TOM1-like protein 1

      Status: VALIDATED

      Source sequence(s)
      BC169112, CK596986, CO568886
      UniProtKB/Swiss-Prot
      F1LM81
      UniProtKB/TrEMBL
      B5DFM1
      Related
      ENSRNOP00000003369.8, ENSRNOT00000003369.8
      Conserved Domains (2) summary
      cd03565
      Location:14 → 154
      VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...
      cd14237
      Location:198 → 289
      GAT_TM1L1; GAT domain found in target of Myb-like protein 1 (Tom1L1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      75961653..76005725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268709.1 → XP_063124779.1  TOM1-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHB0, B5DFM1

    2. XM_039085577.2 → XP_038941505.1  TOM1-like protein 1 isoform X2

      UniProtKB/TrEMBL
      B5DFM1
      Conserved Domains (2) summary
      cd14237
      Location:121 → 212
      GAT_TM1L1; canonical GAT domain found in target of Myb-like protein 1 (Tom1L1)
      cl02544
      Location:1 → 73
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily

    3. XM_039085579.2 → XP_038941507.1  TOM1-like protein 1 isoform X3

      Conserved Domains (1) summary
      cl03906
      Location:1 → 42
      GAT_SF; GAT domain found in eukaryotic GGAs, metazoan Tom1-like proteins, metazoan STAMs, fungal Vps27, and similar proteins

    4. XM_039085578.2 → XP_038941506.1  TOM1-like protein 1 isoform X3

      Conserved Domains (1) summary
      cl03906
      Location:1 → 42
      GAT_SF; GAT domain found in eukaryotic GGAs, metazoan Tom1-like proteins, metazoan STAMs, fungal Vps27, and similar proteins

    RNA

    1. XR_005489750.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1LM81.1 GenPept UniProtKB/Swiss-Prot:F1LM81

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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