Zdhhc17 zinc finger DHHC-type palmitoyltransferase 17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zdhhc17provided by RGD
Official Full Name: zinc finger DHHC-type palmitoyltransferase 17provided by RGD
Primary source: RGD:1595790
See related: EnsemblRapid:ENSRNOG00000003803 AllianceGenome:RGD:1595790
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity; protein-cysteine S-palmitoyltransferase activity; and signaling receptor binding activity. Predicted to be involved in several processes, including establishment of protein localization; peptidyl-L-cysteine S-palmitoylation; and regulation of signal transduction. Predicted to be located in Golgi apparatus and Golgi-associated vesicle membrane. Predicted to be active in Golgi apparatus; glutamatergic synapse; and perforant pathway to dendrate granule cell synapse. Orthologous to human ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 239.4), Adrenal (RPKM 155.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (48256269..48320000, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (46369963..46433691, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (53651529..53715007, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immunohistochemical analysis of pancreatic sections demonstrated that HIP14 is almost exclusively expressed in insulin-positive cells in islets of Langerhans.
Title: Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis.

Submit: New GeneRIF Correction

General gene information

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Markers

D7Rat210 (e-PCR), detects polymorphism
- UniSTS:228159

AU048827 (e-PCR)
- UniSTS:145277

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables palmitoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-cysteine S-myristoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-cysteine S-palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-cysteine S-palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-palmitoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-cysteine S-stearoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipoprotein transport	IEA Inferred from Electronic Annotation more info
involved_in lipoprotein transport	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-L-cysteine S-palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within protein palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in protein palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in protein palmitoylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of modification of synapse structure, modulating synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in regulation of modification of synapse structure, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotrophin TRK receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurotrophin TRK receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotrophin TRK receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in regulation of programmed cell death	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi-associated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi-associated vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in perforant pathway to dendrate granule cell synapse	IEA Inferred from Electronic Annotation more info
is_active_in perforant pathway to dendrate granule cell synapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC17

Names: acyltransferase ZDHHC17; acyltransferase ZDHHC7; membrane-associated DHHC17 zinc finger protein; zinc finger DHHC domain-containing protein 17; zinc finger, DHHC domain containing 17; zinc finger, DHHC-type containing 17

NP_001034429.1

EC 2.3.1.225

XP_063120114.1

EC 2.3.1.225

XP_063120115.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039340.1 → NP_001034429.1 palmitoyltransferase ZDHHC17

See identical proteins and their annotated locations for NP_001034429.1

Status: PROVISIONAL

Source sequence(s)

AY886533

UniProtKB/Swiss-Prot

E9PTT0, Q2TGJ2

Related

ENSRNOP00000005078.6, ENSRNOT00000005078.7

Conserved Domains (5) summary

cd00204
Location:77 → 192

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam01529
Location:428 → 558

zf-DHHC; DHHC palmitoyltransferase

pfam12796
Location:151 → 245

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:60 → 100

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:146 → 177

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

48256269..48320000 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063264044.1 → XP_063120114.1 palmitoyltransferase ZDHHC17 isoform X1

UniProtKB/Swiss-Prot

E9PTT0, Q2TGJ2

UniProtKB/TrEMBL

A0A8L2Q2M2, A6IGF5
XM_063264045.1 → XP_063120115.1 palmitoyltransferase ZDHHC17 isoform X2