Sec23a Sec23 homolog A, COPII coat complex component [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sec23aprovided by RGD
Official Full Name: Sec23 homolog A, COPII coat complex componentprovided by RGD
Primary source: RGD:1309103
See related: EnsemblRapid:ENSRNOG00000004657 AllianceGenome:RGD:1309103
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTPase activator activity and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading and protein localization to plasma membrane. Predicted to be located in bounding membrane of organelle; cytosol; and perinuclear region of cytoplasm. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Human ortholog(s) of this gene implicated in craniolenticulosutural dysplasia. Orthologous to human SEC23A (SEC23 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 284.1), Liver (RPKM 242.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q23

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (82393699..82442594, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (76658793..76706125, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (80059742..80107340, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sec23A expression is upregulated via CREB3L2 during hepatic stellate cells activation. Sec23A knockdown abrogated the activation.
Title: CREB3L2-mediated expression of Sec23A/Sec24D is involved in hepatic stellate cell activation through ER-Golgi transport.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140991 (e-PCR)
- UniSTS:222992

RH128536 (e-PCR)
- UniSTS:211844

RH139244 (e-PCR)
- UniSTS:221330

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in COPII-coated vesicle cargo loading	IBA Inferred from Biological aspect of Ancestor more info
involved_in COPII-coated vesicle cargo loading	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of COPII vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of COPII vesicle coat	ISO Inferred from Sequence Orthology more info
located_in COPII-coated ER to Golgi transport vesicle	ISO Inferred from Sequence Orthology more info
located_in ER to Golgi transport vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum exit site	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein transport protein Sec23A

Names: Sec23 homolog A, coat complex II component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105732.3 → NP_001099202.1 protein transport protein Sec23A isoform 1

See identical proteins and their annotated locations for NP_001099202.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2JZM2, B5DFC3, F7F6X6

Related

ENSRNOP00000006369.4, ENSRNOT00000006369.8

Conserved Domains (1) summary

PLN00162
Location:12 → 763

PLN00162; transport protein sec23; Provisional
NM_001434088.1 → NP_001421017.1 protein transport protein Sec23A isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2JZM2, B5DFC3, F7F6X6
NM_001434089.1 → NP_001421018.1 protein transport protein Sec23A isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2JZM2, B5DFC3, F7F6X6
NM_001434090.1 → NP_001421019.1 protein transport protein Sec23A isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2JZM2, B5DFC3, F7F6X6
NM_001434091.1 → NP_001421020.1 protein transport protein Sec23A isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2JZM2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

82393699..82442594 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262378.1 → XP_063118448.1 protein transport protein Sec23A isoform X1

UniProtKB/TrEMBL

A0A0G2JZM2, B5DFC3, F7F6X6
XM_039112796.2 → XP_038968724.1 protein transport protein Sec23A isoform X1

Conserved Domains (1) summary

PLN00162
Location:12 → 763

PLN00162; transport protein sec23; Provisional
XM_008764661.4 → XP_008762883.1 protein transport protein Sec23A isoform X1

Conserved Domains (1) summary

PLN00162
Location:12 → 763

PLN00162; transport protein sec23; Provisional
XM_063262377.1 → XP_063118447.1 protein transport protein Sec23A isoform X1
XM_039112797.2 → XP_038968725.1 protein transport protein Sec23A isoform X2

Conserved Domains (1) summary

PLN00162
Location:1 → 637

PLN00162; transport protein sec23; Provisional