U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Prss58 serine protease 58 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 408204, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Prss58provided by RGD
    Official Full Name
    serine protease 58provided by RGD
    Primary source
    RGD:1303054
    See related
    EnsemblRapid:ENSRNOG00000013132 AllianceGenome:RGD:1303054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    try1; Tryx3
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be located in extracellular region. Predicted to be active in extracellular space and secretory granule. Orthologous to human PRSS58 (serine protease 58). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 114.9) See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Prss58 in Genome Data Viewer
    Location:
    4q23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (70719326..70731158, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (69752646..69757306, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (69145435..69152111, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene monooxygenase, DBH-like 2 Neighboring gene T-cell receptor beta chain V region E1-like Neighboring gene protease, serine 59 Neighboring gene protease, serine, 3B like 1 Neighboring gene RIKEN cDNA 1810009J06 gene like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Long-term nicotine exposure causes increased concentrations of trypsinogens and amylase in pancreatic extracts in the rat. Lindkvist B, et al. Pancreas, 2008 Oct. PMID 18815551
    2. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nicotine impairs secretion rather than production of pancreatic trypsinogen 1.
      Title: Long-term nicotine exposure causes increased concentrations of trypsinogens and amylase in pancreatic extracts in the rat.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    putative inactive serine protease 58
    Names
    protease, serine, 58
    putative trypsin-X3
    trypsin-X3
    NP_001009174.1
    XP_017448227.1
    XP_038963897.1
    XP_063142477.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009174.2 → NP_001009174.1  putative inactive serine protease 58 precursor

      See identical proteins and their annotated locations for NP_001009174.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q6IE06
      UniProtKB/TrEMBL
      A6IEZ5
      Related
      ENSRNOP00000017611.3, ENSRNOT00000017611.6
      Conserved Domains (1) summary
      smart00020
      Location:28 → 233
      Tryp_SPc; Trypsin-like serine protease

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      70719326..70731158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286407.1 → XP_063142477.1  putative inactive serine protease 58 isoform X1

      UniProtKB/Swiss-Prot
      Q6IE06
      UniProtKB/TrEMBL
      A6IEZ5

    2. XM_039107969.2 → XP_038963897.1  putative inactive serine protease 58 isoform X1

      UniProtKB/Swiss-Prot
      Q6IE06
      UniProtKB/TrEMBL
      A6IEZ5
      Conserved Domains (1) summary
      smart00020
      Location:28 → 233
      Tryp_SPc; Trypsin-like serine protease

    3. XM_017592738.2 → XP_017448227.1  putative inactive serine protease 58 isoform X1

      UniProtKB/Swiss-Prot
      Q6IE06
      UniProtKB/TrEMBL
      A6IEZ5
      Conserved Domains (1) summary
      smart00020
      Location:28 → 233
      Tryp_SPc; Trypsin-like serine protease
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IE06.1 GenPept UniProtKB/Swiss-Prot:Q6IE06

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools