Txndc12 thioredoxin domain containing 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Txndc12provided by RGD
Official Full Name: thioredoxin domain containing 12provided by RGD
Primary source: RGD:1305960
See related: EnsemblRapid:ENSRNOG00000008090 AllianceGenome:RGD:1305960
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305960
Summary: Predicted to enable protein-disulfide reductase (glutathione) activity. Predicted to act upstream of or within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in endoplasmic reticulum lumen. Orthologous to human TXNDC12 (thioredoxin domain containing 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 300.8), Heart (RPKM 275.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (128815471..128841574)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (123587854..123612886)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (128450830..128475858)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ERp16 mediates disulfide bond formation in the ER and plays an important role in cellular defense against prolonged ER stress
Title: ERp16, an endoplasmic reticulum-resident thiol-disulfide oxidoreductase: biochemical properties and role in apoptosis induced by endoplasmic reticulum stress.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128551 (e-PCR)
- UniSTS:211859

RH128568 (e-PCR)
- UniSTS:211876

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein-disulfide reductase (glutathione) activity	IEA Inferred from Electronic Annotation more info
enables protein-disulfide reductase (glutathione) activity	ISO Inferred from Sequence Orthology more info
enables protein-disulfide reductase (glutathione) activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-disulfide reductase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thioredoxin domain-containing protein 12

Names: thioredoxin domain containing 12 (endoplasmic reticulum)

NP_001094310.1

EC 1.8.4.2

XP_063143462.1

EC 1.8.4.2

XP_063143463.1

EC 1.8.4.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100840.1 → NP_001094310.1 thioredoxin domain-containing protein 12 precursor

See identical proteins and their annotated locations for NP_001094310.1

Status: VALIDATED

Source sequence(s)

BC100255, CV117277

UniProtKB/Swiss-Prot

Q498E0

UniProtKB/TrEMBL

A6JYW6, B0BN97

Conserved Domains (1) summary

cd02959
Location:34 → 150

ERp19; Endoplasmic reticulum protein 19 (ERp19) family; ERp19 is also known as ERp18, a protein located in the ER containing one redox active TRX domain. Denaturation studies indicate that the reduced form is more stable than the oxidized form, suggesting that ...