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    Gja10 gap junction protein, alpha 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313126, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gja10provided by RGD
    Official Full Name
    gap junction protein, alpha 10provided by RGD
    Primary source
    RGD:1309630
    See related
    EnsemblRapid:ENSRNOG00000006478 AllianceGenome:RGD:1309630
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cx57; Cxnn; Cx-57; RGD1309630
    Summary
    Predicted to enable gap junction channel activity. Predicted to be involved in cell-cell signaling. Predicted to act upstream of or within detection of light stimulus involved in visual perception; gamete generation; and synapse assembly. Predicted to be located in gap junction. Predicted to be part of connexin complex. Orthologous to human GJA10 (gap junction protein alpha 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 4.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gja10 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (51787407..51799827, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (46991051..47002902, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (47819484..47841138, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102849 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene BTB domain and CNC homolog 2 Neighboring gene uncharacterized LOC120102851 Neighboring gene caspase 8 associated protein 2 Neighboring gene midasin AAA ATPase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Horizontal cell receptive fields are reduced in connexin57-deficient mice. Shelley J, et al. Eur J Neurosci, 2006 Jun. PMID 16820008
    2. Molecular cloning and functional expression of the mouse gap junction gene connexin-57 in human HeLa cells. Manthey D, et al. J Biol Chem, 1999 May 21. PMID 10329667
    3. Functional expression of connexin57 in horizontal cells of the mouse retina. Hombach S, et al. Eur J Neurosci, 2004 May. PMID 15147297
    4. The detection of hamster connexins: a comparison of expression profiles with wild-type mouse and the cancer-prone Min mouse. Cruciani V, et al. Cell Commun Adhes, 2004 Sep-Dec. PMID 16194882
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gap junction channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within detection of light stimulus involved in visual perception ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gamete generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to light stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of connexin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gap junction alpha-10 protein
    Names
    connexin 57
    connexin n
    gap junction membrane channel protein alpha 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411855.1 → NP_001398784.1  gap junction alpha-10 protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      F1LPI3, Q80XY0
      Related
      ENSRNOP00000100100.1, ENSRNOT00000159977.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      51787407..51799827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008763619.4 → XP_008761841.1  gap junction alpha-10 protein isoform X1

      UniProtKB/TrEMBL
      A0A654ID08, Q80XY0
      Conserved Domains (1) summary
      pfam00029
      Location:3 → 235
      Connexin

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001173508.1: Suppressed sequence

      Description
      NM_001173508.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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