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    Hormad1 HORMA domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365868, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hormad1provided by RGD
    Official Full Name
    HORMA domain containing 1provided by RGD
    Primary source
    RGD:1564960
    See related
    EnsemblRapid:ENSRNOG00000021160 AllianceGenome:RGD:1564960
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564960
    Summary
    Predicted to be involved in several processes, including meiosis I cell cycle process; meiotic sister chromatid cohesion; and regulation of cell cycle process. Predicted to act upstream of or within homologous chromosome pairing at meiosis. Predicted to be located in cytoplasm and synaptonemal complex. Orthologous to human HORMAD1 (HORMA domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 123.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hormad1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185803572..185841449)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183115815..183152383)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (197681820..197720197)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ataxin-8-like Neighboring gene cathepsin S Neighboring gene transfer RNA leucine (anticodon AAG) 16 Neighboring gene golgi phosphoprotein 3-like Neighboring gene RNA, U6 small nuclear 857 Neighboring gene endosulfine alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel mammalian HORMA domain-containing protein, HORMAD1, preferentially associates with unsynapsed meiotic chromosomes. Fukuda T, et al. Exp Cell Res, 2010 Jan 15. PMID 19686734
    2. Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase. Wojtasz L, et al. PLoS Genet, 2009 Oct. PMID 19851446, Free PMC Article
    3. Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms. Wojtasz L, et al. Genes Dev, 2012 May 1. PMID 22549958, Free PMC Article
    4. Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. Shin YH, et al. PLoS Genet, 2010 Nov 4. PMID 21079677, Free PMC Article
    5. HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes. Kogo H, et al. Genes Cells, 2012 Jun. PMID 22530760

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in blastocyst development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in blastocyst development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic DNA double-strand break formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic DNA double-strand break formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within meiotic recombination checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic recombination checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic recombination checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in meiotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic sister chromatid cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of homologous chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of homologous chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synaptonemal complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptonemal complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synaptonemal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    HORMA domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108949.1 → NP_001102419.1  HORMA domain-containing protein 1

      See identical proteins and their annotated locations for NP_001102419.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474015
      UniProtKB/Swiss-Prot
      D3ZWE7, D3ZZR2
      UniProtKB/TrEMBL
      A0A8I5ZSL6
      Related
      ENSRNOP00000105827.1, ENSRNOT00000154721.1
      Conserved Domains (1) summary
      pfam02301
      Location:27 → 221
      HORMA; HORMA domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      185803572..185841449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102781.2 → XP_038958709.1  HORMA domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZWE7, D3ZZR2
      UniProtKB/TrEMBL
      A0A8I5ZSL6
      Conserved Domains (1) summary
      pfam02301
      Location:27 → 221
      HORMA; HORMA domain

    2. XM_063282273.1 → XP_063138343.1  HORMA domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZWE7, D3ZZR2
      UniProtKB/TrEMBL
      A0A8I5ZSL6

    3. XM_006232951.5 → XP_006233013.1  HORMA domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006233013.1

      UniProtKB/Swiss-Prot
      D3ZWE7, D3ZZR2
      UniProtKB/TrEMBL
      A0A8I5ZSL6
      Related
      ENSRNOP00000063863.1, ENSRNOT00000066821.3
      Conserved Domains (1) summary
      pfam02301
      Location:27 → 221
      HORMA; HORMA domain

    4. XM_039102783.2 → XP_038958711.1  HORMA domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      pfam02301
      Location:27 → 187
      HORMA; HORMA domain

    5. XM_039102782.2 → XP_038958710.1  HORMA domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      pfam02301
      Location:2 → 93
      HORMA; HORMA domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZWE7.1 GenPept UniProtKB/Swiss-Prot:D3ZWE7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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