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    Dbf4 DBF4-CDC7 kinase regulatory subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312046, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dbf4provided by RGD
    Official Full Name
    DBF4-CDC7 kinase regulatory subunitprovided by RGD
    Primary source
    RGD:1305854
    See related
    EnsemblRapid:ENSRNOG00000050482 AllianceGenome:RGD:1305854
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305854
    Summary
    Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication and regulation of cell cycle phase transition. Predicted to be located in nuclear body. Predicted to be part of Dbf4-dependent protein kinase complex. Orthologous to human DBF4 (DBF4-CDC7 kinase regulatory subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 109.7), Spleen (RPKM 77.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dbf4 in Genome Data Viewer
    Location:
    4q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (26631491..26656080)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (25676570..25701152)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (22898527..22914091)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily B member 1A Neighboring gene RUN domain containing 3B Neighboring gene solute carrier family 25, member 40 Neighboring gene ADAM metallopeptidase domain 22 Neighboring gene transfer RNA proline (anticodon AGG) 72 Neighboring gene uncharacterized LOC120102223

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of Chinese hamster homologue of yeast DBF4 (ChDBF4). Guo B, et al. Gene, 2001 Feb 21. PMID 11250080
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of nuclear cell cycle DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Dbf4-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein DBF4 homolog A
    Names
    DBF4 homolog
    DBF4 zinc finger
    protein DBF4 homolog A-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191748.2 → NP_001178677.1  protein DBF4 homolog A

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A096MJF6
      Related
      ENSRNOP00000068111.2, ENSRNOT00000076123.4
      Conserved Domains (2) summary
      cd00027
      Location:48 → 94
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cl02684
      Location:288 → 335
      zf-DBF; DBF zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      26631491..26656080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107501.2 → XP_038963429.1  protein DBF4 homolog A isoform X1

      Conserved Domains (1) summary
      cl02684
      Location:287 → 334
      zf-DBF; DBF zinc finger

    2. XM_039107502.2 → XP_038963430.1  protein DBF4 homolog A isoform X2

      UniProtKB/TrEMBL
      A6K240
      Conserved Domains (1) summary
      cl02684
      Location:50 → 97
      zf-DBF; DBF zinc finger

    3. XM_039107503.2 → XP_038963431.1  protein DBF4 homolog A isoform X2

      UniProtKB/TrEMBL
      A6K240
      Conserved Domains (1) summary
      cl02684
      Location:50 → 97
      zf-DBF; DBF zinc finger
    Nucleotide Protein Strain
    Heading Accession and Version

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