Padi6 peptidyl arginine deiminase 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Padi6provided by RGD
Official Full Name: peptidyl arginine deiminase 6provided by RGD
Primary source: RGD:1560424
See related: EnsemblRapid:ENSRNOG00000037079 AllianceGenome:RGD:1560424
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560424
Summary: Predicted to enable protein-arginine deiminase activity. Predicted to be involved in embryonic cleavage. Predicted to act upstream of or within cytoplasm organization; cytoskeleton organization; and regulation of translation by machinery localization. Predicted to be located in cortical granule and intermediate filament cytoskeleton. Predicted to be active in cytoplasm and nucleus. Orthologous to human PADI6 (peptidyl arginine deiminase 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 7.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (158304118..158320508, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (153021855..153037443, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (159241276..159256749, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables histone H1R54 arginine deiminase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AR3 arginine deiminase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R17 arginine deiminase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R2 arginine deiminase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R26 arginine deiminase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R8 arginine deiminase activity	IEA Inferred from Electronic Annotation more info
enables histone H4R3 arginine deiminase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein-arginine deiminase activity	IBA Inferred from Biological aspect of Ancestor more info
NOT contributes_to protein-arginine deiminase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine deiminase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytoplasm organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in embryonic cleavage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation by machinery localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cortical granule	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein-arginine deiminase type-6

Names: peptidyl arginine deiminase, type VI

NP_001178695.2

EC 3.5.3.15

XP_063143541.1

EC 3.5.3.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191766.3 → NP_001178695.2 protein-arginine deiminase type-6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

Conserved Domains (1) summary

cl19115
Location:7 → 113

Cupredoxin; Cupredoxin superfamily