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    Plekha8 pleckstrin homology domain containing A8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500132, updated on 9-Dec-2024

    Summary

    Official Symbol
    Plekha8provided by RGD
    Official Full Name
    pleckstrin homology domain containing A8provided by RGD
    Primary source
    RGD:1563940
    See related
    EnsemblRapid:ENSRNOG00000009971 AllianceGenome:RGD:1563940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    FAPP-2; RGD1563940
    Summary
    Predicted to enable several functions, including identical protein binding activity; lipid transfer activity; and phospholipid binding activity. Predicted to be involved in ER to Golgi ceramide transport and intermembrane lipid transfer. Predicted to be located in nucleoplasm and trans-Golgi network. Predicted to be active in cytosol. Orthologous to several human genes including PLEKHA8 (pleckstrin homology domain containing A8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 55.4), Testes (RPKM 46.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Plekha8 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (85053765..85104376)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (83723470..83774081)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (84770294..84820887)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene secernin 1 Neighboring gene uncharacterized LOC102553885 Neighboring gene FKBP prolyl isomerase 14 Neighboring gene translocase of outer mitochondrial membrane 7, pseudogene 3 Neighboring gene uncharacterized LOC134486771 Neighboring gene maturin, neural progenitor differentiation regulator homolog Neighboring gene uncharacterized LOC100909941

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ceramide 1-phosphate binding  
    enables ceramide 1-phosphate transfer activity  
    enables ceramide binding  
    enables ceramide binding  
    enables glycolipid binding  
    enables glycolipid binding  
    enables glycolipid transfer activity  
    enables glycolipid transfer activity  
    enables identical protein binding  
    enables phosphatidylinositol-4-phosphate binding  
    enables phosphatidylinositol-4-phosphate binding  
    Process Evidence Code Pubs
    involved_in ER to Golgi ceramide transport  
    involved_in ER to Golgi ceramide transport  
    involved_in ceramide 1-phosphate transport  
    involved_in ceramide transport  
    involved_in glycolipid transport  
    involved_in intermembrane lipid transfer  
    involved_in lipid transport  
    involved_in lipid transport  
    involved_in protein transport  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    is_active_in cytosol  
    located_in membrane  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in trans-Golgi network  
    located_in trans-Golgi network  

    General protein information

    Preferred Names
    pleckstrin homology domain-containing family A member 8
    Names
    PH domain-containing family A member 8
    phosphatidylinositol-four-phosphate adapter protein 2
    phosphoinositol 4-phosphate adapter protein 2
    pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109235.2NP_001102705.1  pleckstrin homology domain-containing family A member 8

      See identical proteins and their annotated locations for NP_001102705.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      D3ZY60
      Related
      ENSRNOP00000013528.6, ENSRNOT00000013528.8
      Conserved Domains (3) summary
      cd01247
      Location:1100
      PH_FAPP1_FAPP2; Four phosphate adaptor protein 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:193
      PH; PH domain
      pfam08718
      Location:334471
      GLTP; Glycolipid transfer protein (GLTP)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      85053765..85104376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108138.2XP_038964066.1  pleckstrin homology domain-containing family A member 8 isoform X1

      Conserved Domains (1) summary
      cd01247
      Location:1100
      PH_FAPP1_FAPP2; Four phosphate adaptor protein 1 and 2 Pleckstrin homology (PH) domain
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