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    Tmc5 transmembrane channel-like 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365360, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmc5provided by RGD
    Official Full Name
    transmembrane channel-like 5provided by RGD
    Primary source
    RGD:1307037
    See related
    EnsemblRapid:ENSRNOG00000036760 AllianceGenome:RGD:1307037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mechanosensitive monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in plasma membrane. Orthologous to human TMC5 (transmembrane channel like 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 136.1) and Lung (RPKM 10.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmc5 in Genome Data Viewer
    Location:
    1q35
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (182349102..182433679)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (172914915..172999478)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (188288738..188337310)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099916 Neighboring gene ubiquitin-like protein FUBI-like Neighboring gene coenzyme Q7, hydroxylase Neighboring gene transmembrane channel-like 7 Neighboring gene uncharacterized LOC120099917 Neighboring gene glycerophosphodiester phosphodiesterase 1 Neighboring gene centriolar coiled-coil protein 110

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
    2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane channel-like protein 5
    Names
    transmembrane channel-like gene family 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012216.1 → NP_001012216.1  transmembrane channel-like protein 5 isoform 2

      See identical proteins and their annotated locations for NP_001012216.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088406
      UniProtKB/TrEMBL
      D3ZTH0
      Related
      ENSRNOP00000051978.5, ENSRNOT00000055103.6
      Conserved Domains (1) summary
      pfam07810
      Location:481 → 577
      TMC; TMC domain

    2. NM_001401626.2 → NP_001388555.1  transmembrane channel-like protein 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q5M7W4
      UniProtKB/TrEMBL
      F1LRQ5
      Related
      ENSRNOP00000097174.1, ENSRNOT00000096952.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      182349102..182433679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085213.2 → XP_038941141.1  transmembrane channel-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q5M7W4
      UniProtKB/TrEMBL
      F1LRQ5
      Conserved Domains (1) summary
      pfam07810
      Location:683 → 789
      TMC; TMC domain

    2. XM_039085220.2 → XP_038941148.1  transmembrane channel-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q5M7W4
      UniProtKB/TrEMBL
      F1LRQ5
      Conserved Domains (1) summary
      pfam07810
      Location:683 → 789
      TMC; TMC domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M7W4.2 GenPept UniProtKB/Swiss-Prot:Q5M7W4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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