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    Dusp15 dual specificity phosphatase 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362238, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dusp15provided by RGD
    Official Full Name
    dual specificity phosphatase 15provided by RGD
    Primary source
    RGD:1305990
    See related
    EnsemblRapid:ENSRNOG00000008534 AllianceGenome:RGD:1305990
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of ERK1 and ERK2 cascade. Predicted to be active in cytosol and plasma membrane. Orthologous to human DUSP15 (dual specificity phosphatase 15). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 217.5), Kidney (RPKM 93.8) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dusp15 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (161868746..161880432, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (141408495..141419137, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (148417990..148428494, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene myosin light chain kinase 2 Neighboring gene forkhead box S1 Neighboring gene tubulin tyrosine ligase like 9 Neighboring gene uncharacterized LOC134486186 Neighboring gene p53 and DNA damage regulated 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dual specificity phosphatase 15 regulates Erk activation in Schwann cells. Rodríguez-Molina JF, et al. J Neurochem, 2017 Feb. PMID 27891578, Free PMC Article
    2. Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach. Schmidt F, et al. PLoS One, 2012. PMID 22792334, Free PMC Article
    3. Identification and characterization of DUSP27, a novel dual-specific protein phosphatase. Friedberg I, et al. FEBS Lett, 2007 May 29. PMID 17498703
    4. The family-wide structure and function of human dual-specificity protein phosphatases. Jeong DG, et al. Acta Crystallogr D Biol Crystallogr, 2014 Feb. PMID 24531476
    5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 15
    Names
    dual specificity phosphatase-like 15
    NP_001102068.2
    NP_001231713.1
    XP_038961415.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108598.2 → NP_001102068.2  dual specificity protein phosphatase 15 isoform 1

      See identical proteins and their annotated locations for NP_001102068.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC168211, CB576376, CB585518
      UniProtKB/TrEMBL
      A0A8I5YCB5, A6KHS5, M0RD87
      Related
      ENSRNOP00000093117.1, ENSRNOT00000095914.2
      Conserved Domains (1) summary
      cd00127
      Location:4 → 146
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    2. NM_001244784.1 → NP_001231713.1  dual specificity protein phosphatase 15 isoform 2

      See identical proteins and their annotated locations for NP_001231713.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      BC168211, CB736780
      UniProtKB/Swiss-Prot
      B4F7B7
      UniProtKB/TrEMBL
      A0A8I5YCB5
      Related
      ENSRNOP00000011350.6, ENSRNOT00000011350.9
      Conserved Domains (1) summary
      cd14582
      Location:1 → 146
      DSP_DUSP15; dual specificity phosphatase domain of dual specificity protein phosphatase 15

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      161868746..161880432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105487.2 → XP_038961415.1  dual specificity protein phosphatase 15 isoform X1

      Conserved Domains (1) summary
      cl28904
      Location:1 → 121
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RNA

    1. XR_005501941.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B4F7B7.1 GenPept UniProtKB/Swiss-Prot:B4F7B7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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