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    Elovl7 ELOVL fatty acid elongase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361895, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Elovl7provided by RGD
    Official Full Name
    ELOVL fatty acid elongase 7provided by RGD
    Primary source
    RGD:1310560
    See related
    EnsemblRapid:ENSRNOG00000010450 AllianceGenome:RGD:1310560
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ELOVL7 (ELOVL fatty acid elongase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 248.6), Adrenal (RPKM 248.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Elovl7 in Genome Data Viewer
    Location:
    2q14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (41522695..41592021)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (39789229..39858579)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (40373211..40386643, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29, pseudogene 23 Neighboring gene egl-9 family hypoxia-inducible factor 1, pseudogene 5 Neighboring gene uncharacterized LOC134485833 Neighboring gene uncharacterized LOC108350211 Neighboring gene DEP domain containing 1B Neighboring gene phosphodiesterase 4D Neighboring gene uncharacterized LOC120101083

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism. Tamura K, et al. Cancer Res, 2009 Oct 15. PMID 19826053
    2. ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. Ohno Y, et al. Proc Natl Acad Sci U S A, 2010 Oct 26. PMID 20937905, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fatty acid elongase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid elongase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid elongase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation, monounsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, polyunsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, polyunsaturated fatty acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation, polyunsaturated fatty acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty-acyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in unsaturated fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    very long chain fatty acid elongase 7
    Names
    3-keto acyl-CoA synthase Elovl7
    ELOVL FA elongase 7
    elongation of very long chain fatty acids protein 7
    very long chain 3-ketoacyl-CoA synthase 7
    very long chain 3-oxoacyl-CoA synthase 7
    NP_001178773.1
    XP_038958484.1
    XP_038958485.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191844.1 → NP_001178773.1  very long chain fatty acid elongase 7

      See identical proteins and their annotated locations for NP_001178773.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      D4ADY9
      UniProtKB/TrEMBL
      A0A8I6A659
      Conserved Domains (1) summary
      pfam01151
      Location:30 → 269
      ELO; GNS1/SUR4 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      41522695..41592021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102556.2 → XP_038958484.1  very long chain fatty acid elongase 7 isoform X1

      UniProtKB/Swiss-Prot
      D4ADY9
      UniProtKB/TrEMBL
      A0A8I6A659
      Related
      ENSRNOP00000014074.5, ENSRNOT00000014074.7
      Conserved Domains (1) summary
      pfam01151
      Location:30 → 269
      ELO; GNS1/SUR4 family

    2. XM_039102557.2 → XP_038958485.1  very long chain fatty acid elongase 7 isoform X2

      UniProtKB/TrEMBL
      A0A0A0MXW4
      Conserved Domains (1) summary
      pfam01151
      Location:1 → 182
      ELO; GNS1/SUR4 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4ADY9.1 GenPept UniProtKB/Swiss-Prot:D4ADY9

    Gene LinkOut

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