Pdss1 decaprenyl diphosphate synthase subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pdss1provided by RGD
Official Full Name: decaprenyl diphosphate synthase subunit 1provided by RGD
Primary source: RGD:2319976
See related: EnsemblRapid:ENSRNOG00000048849 AllianceGenome:RGD:2319976
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable prenyltransferase activity and protein heterodimerization activity. Predicted to contribute to all-trans-decaprenyl-diphosphate synthase activity and all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity. Predicted to be involved in isoprenoid biosynthetic process and ubiquinone biosynthetic process. Predicted to be part of heterotetrameric polyprenyl diphosphate synthase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 2. Orthologous to human PDSS1 (decaprenyl diphosphate synthase subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 62.1), Heart (RPKM 50.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (89964768..90006819)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (85059953..85098739)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (90033432..90072506, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to all-trans-decaprenyl-diphosphate synthase activity	ISO Inferred from Sequence Orthology more info
contributes_to all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity	ISO Inferred from Sequence Orthology more info
enables prenyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in isoprenoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isoprenoid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquinone biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of heterotetrameric polyprenyl diphosphate synthase complex	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
part_of polyprenyl diphosphate synthase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: all trans-polyprenyl-diphosphate synthase PDSS1

Names: COenzyme Q (ubiquinone) biosynthesis family member (coq-1)-like; prenyl (decaprenyl) diphosphate synthase, subunit 1

NP_001387776.1

EC 2.5.1.91

XP_038952272.1

EC 2.5.1.91

XP_038952273.1

EC 2.5.1.91

XP_063132077.1

EC 2.5.1.91

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001400847.1 → NP_001387776.1 all trans-polyprenyl-diphosphate synthase PDSS1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A6KRZ8, B0BN60

Related

ENSRNOP00000065114.2, ENSRNOT00000071978.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

89964768..90006819

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096345.2 → XP_038952273.1 all trans-polyprenyl-diphosphate synthase PDSS1 isoform X3

Conserved Domains (1) summary

PLN02890
Location:74 → 236

PLN02890; geranyl diphosphate synthase
XM_039096344.2 → XP_038952272.1 all trans-polyprenyl-diphosphate synthase PDSS1 isoform X2

UniProtKB/TrEMBL

B0BN60

Conserved Domains (1) summary

PLN02890
Location:11 → 336

PLN02890; geranyl diphosphate synthase
XM_063276007.1 → XP_063132077.1 all trans-polyprenyl-diphosphate synthase PDSS1 isoform X1

UniProtKB/TrEMBL

B0BN60