RT1-CE15 RT1 class I, locus CE15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: RT1-CE15provided by RGD
Full Name: RT1 class I, locus CE15provided by RGD
Primary source: RGD:1359630
See related: AllianceGenome:RGD:1359630
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis and viral translational frameshifting. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-E (major histocompatibility complex, class I, E). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 20p12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (3269135..3283819, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (3275575..3279074, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D20Wox4 (e-PCR)
- UniSTS:118079

D20Wox23 (e-PCR)
- UniSTS:518782

D20Mgh3 (e-PCR)
- UniSTS:227288

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RT1 class I, locus CE15

Names: RT1 class I histocompatibility antigen, AA alpha chain; RT1 class I, CE15; RT1 class I, CE15 mature; RT1 class I, locus CE11-like; class I histocompatibility antigen, Non-RT1.A alpha-1 chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008838.2 → NP_001008838.1 RT1 class I, locus CE15 precursor

See identical proteins and their annotated locations for NP_001008838.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A2P1NRY8, Q6MG29

Conserved Domains (3) summary

cd07698
Location:207 → 299

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00129
Location:26 → 203

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

pfam06623
Location:345 → 371

MHC_I_C; MHC_I C-terminus