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    Sumf1 sulfatase modifying factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362409, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Sumf1provided by RGD
    Official Full Name
    sulfatase modifying factor 1provided by RGD
    Primary source
    RGD:1309939
    See related
    EnsemblRapid:ENSRNOG00000006813 AllianceGenome:RGD:1309939
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable formylglycine-generating oxidase activity and identical protein binding activity. Predicted to be involved in post-translational protein modification. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in mucosulfatidosis. Orthologous to human SUMF1 (sulfatase modifying factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 114.8), Lung (RPKM 77.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sumf1 in Genome Data Viewer
    Location:
    4q41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (142634766..142716726, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (141078735..141160711, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (140139017..140220482, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486830 Neighboring gene SET domain and mariner transposase fusion gene Neighboring gene uncharacterized LOC134486831 Neighboring gene inositol 1,4,5-trisphosphate receptor, type 1 Neighboring gene uncharacterized LOC102547466 Neighboring gene uncharacterized LOC108350742

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion. Holder PG, et al. J Biol Chem, 2015 Jun 19. PMID 25931126, Free PMC Article
    2. SUMF1 mutations affecting stability and activity of formylglycine generating enzyme predict clinical outcome in multiple sulfatase deficiency. Schlotawa L, et al. Eur J Hum Genet, 2011 Mar. PMID 21224894, Free PMC Article
    3. Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C(alpha)-formylglycine generating enzyme. Dierks T, et al. Cell, 2003 May 16. PMID 12757705
    4. Paralog of the formylglycine-generating enzyme--retention in the endoplasmic reticulum by canonical and noncanonical signals. Gande SL, et al. FEBS J, 2008 Mar. PMID 18266766
    5. Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2. Zito E, et al. EMBO Rep, 2005 Jul. PMID 15962010, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cupric ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables formylglycine-generating oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in post-translational protein modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    formylglycine-generating enzyme
    NP_001102109.1
    XP_038963755.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108639.1 → NP_001102109.1  formylglycine-generating enzyme precursor

      See identical proteins and their annotated locations for NP_001102109.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473957
      UniProtKB/TrEMBL
      A0A8I5ZM54, A6IBK9, D4A7I8
      Related
      ENSRNOP00000009008.4, ENSRNOT00000009008.7
      Conserved Domains (2) summary
      TIGR03525
      Location:89 → 372
      GldK; gliding motility-associated lipoprotein GldK
      pfam03781
      Location:86 → 365
      FGE-sulfatase; Sulfatase-modifying factor enzyme 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      142634766..142716726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107827.2 → XP_038963755.1  formylglycine-generating enzyme isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZM54
      Related
      ENSRNOP00000079041.2, ENSRNOT00000115716.2
      Conserved Domains (1) summary
      pfam03781
      Location:86 → 345
      FGE-sulfatase; Sulfatase-modifying factor enzyme 1
    Nucleotide Protein Strain
    Heading Accession and Version

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