Slc30a8 solute carrier family 30 member 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc30a8provided by RGD
Official Full Name: solute carrier family 30 member 8provided by RGD
Primary source: RGD:1308282
See related: EnsemblRapid:ENSRNOG00000004747 AllianceGenome:RGD:1308282
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ZnT-8
Summary: Enables zinc ion transmembrane transporter activity. Involved in several processes, including insulin secretion; positive regulation of insulin secretion; and zinc ion import across plasma membrane. Predicted to be located in secretory granule membrane. Predicted to be active in plasma membrane and secretory granule. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC30A8 (solute carrier family 30 member 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 1.1), Spleen (RPKM 0.7) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q31

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (85481864..85517255)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (83591993..83627786)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (91832988..91869329)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In diabetic retinas, EPO maintains zinc homeostasis through activating the ERK pathway and downregulating HIF-1alpha, and thus upregulating ZnT8 expression.
Title: Erythropoietin Protects Retinal Cells in Diabetic Rats Through Upregulating ZnT8 via Activating ERK Pathway and Inhibiting HIF-1α Expression.
Diabetes caused reductions in the serum and pancreatic zinc levels and pancreatic ZnT8 expression. Following moderate exercise training, there was a significant increase in all of these parameters.
Title: Moderate-intensity exercise training elevates serum and pancreatic zinc levels and pancreatic ZnT8 expression in streptozotocin-induced diabetic rats.
ischemic retinopathy maybe mediated by aberrant Zn(++) homeostasis caused by ZnT8 downregulation, whereas YC-1 plays a neuroprotective role against ischemic insult
Title: Zinc transporter 8 (ZnT8) expression is reduced by ischemic insults: a potential therapeutic target to prevent ischemic retinopathy.
Both ZnT3 and ZnT8 seem to play a role in beta-cell survival and the ability of these cells to react appropriately to surrounding glucose concentrations.
Title: siRNA-mediated knock-down of ZnT3 and ZnT8 affects production and secretion of insulin and apoptosis in INS-1E cells.
Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands.
Title: Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands.
These data indicate that reduced ZnT8 expression in cultured pancreatic beta cells gives rise to a reduced insulin response to hyperglycemia.
Title: Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables zinc:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables zinc:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
NOT involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in insulin processing	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to glucose	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to glucose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to glucose	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zinc ion import into organelle	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into organelle	ISS Inferred from Sequence or Structural Similarity more info
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule membrane	ISO Inferred from Sequence Orthology more info
located_in secretory granule membrane	ISO Inferred from Sequence Orthology more info
located_in secretory granule membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proton-coupled zinc antiporter SLC30A8

Names: solute carrier family 30 (zinc transporter), member 8; zinc transporter 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130538.1 → NP_001124010.1 proton-coupled zinc antiporter SLC30A8

See identical proteins and their annotated locations for NP_001124010.1

Status: PROVISIONAL

Source sequence(s)

CH473950

UniProtKB/Swiss-Prot

P0CE46

UniProtKB/TrEMBL

A0A0H2UHD4

Conserved Domains (2) summary

TIGR01297
Location:82 → 318

CDF; cation diffusion facilitator family transporter

pfam01545
Location:83 → 273

Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

85481864..85517255

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241645.5 → XP_006241707.1 proton-coupled zinc antiporter SLC30A8 isoform X1

See identical proteins and their annotated locations for XP_006241707.1

UniProtKB/Swiss-Prot

P0CE46

Related

ENSRNOP00000006410.7, ENSRNOT00000006410.8

Conserved Domains (1) summary

TIGR01297
Location:82 → 353

CDF; cation diffusion facilitator family transporter
XM_008765500.4 → XP_008763722.1 proton-coupled zinc antiporter SLC30A8 isoform X2

Conserved Domains (2) summary

TIGR01297
Location:83 → 354

CDF; cation diffusion facilitator family transporter

pfam01545
Location:84 → 274

Cation_efflux; Cation efflux family