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    Slc1a7 solute carrier family 1 member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366432, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Slc1a7provided by RGD
    Official Full Name
    solute carrier family 1 member 7provided by RGD
    Primary source
    RGD:1311928
    See related
    EnsemblRapid:ENSRNOG00000011644 AllianceGenome:RGD:1311928
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable amino acid transmembrane transporter activity and extracellularly glutamate-gated chloride channel activity. Predicted to be involved in L-glutamate transmembrane transport; chloride transmembrane transport; and neurotransmitter uptake. Predicted to act upstream of or within monoatomic anion transmembrane transport. Predicted to be located in photoreceptor cell terminal bouton. Predicted to be active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Orthologous to human SLC1A7 (solute carrier family 1 member 7). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 9.9), Lung (RPKM 6.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc1a7 in Genome Data Viewer
    Location:
    5q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (127959769..128003899)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (122731003..122775139)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (127571114..127616033)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing, antiviral 1, pseudogene 9 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene podocan Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Excitatory amino acid transporter 5 is widely expressed in peripheral tissues. Lee A, et al. Eur J Histochem, 2013 Mar 12. PMID 23549460, Free PMC Article
    2. Alternate splicing and expression of the glutamate transporter EAAT5 in the rat retina. Lee A, et al. Gene, 2012 Sep 15. PMID 22820393
    3. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Arriza JL, et al. Proc Natl Acad Sci U S A, 1997 Apr 15. PMID 9108121, Free PMC Article
    4. Functional properties of the retinal glutamate transporters GLT-1c and EAAT5. Schneider N, et al. J Biol Chem, 2014 Jan 17. PMID 24307171, Free PMC Article
    5. Glutamate transporters EAAT4 and EAAT5 are expressed in vestibular hair cells and calyx endings. Dalet A, et al. PLoS One, 2012. PMID 23049999, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EAAT5 is a widely distributed protein. Whether it functions in all locations as a glutamate transporter, or mainly as a glutamate-gated chloride conductance, remains to be determined.
      Title: Excitatory amino acid transporter 5 is widely expressed in peripheral tissues.
    2. EAAT5 exists in multiple spliced forms in the rat retina
      Title: Alternate splicing and expression of the glutamate transporter EAAT5 in the rat retina.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-glutamate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables extracellularly glutamate-gated chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutamate:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-glutamate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within L-glutamate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-glutamate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic anion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter uptake ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutral amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor cell terminal bouton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    excitatory amino acid transporter 5
    Names
    EAAT5
    solute carrier family 1 (glutamate transporter), member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108973.1 → NP_001102443.1  excitatory amino acid transporter 5

      See identical proteins and their annotated locations for NP_001102443.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474008
      UniProtKB/TrEMBL
      A6JYT8, D3ZT83, F2YRM7
      Related
      ENSRNOP00000016557.3, ENSRNOT00000016557.8
      Conserved Domains (1) summary
      pfam00375
      Location:29 → 486
      SDF; Sodium:dicarboxylate symporter family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      127959769..128003899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593537.3 → XP_017449026.1  excitatory amino acid transporter 5 isoform X1

      UniProtKB/TrEMBL
      F2YRM5, F2YRM7
      Conserved Domains (1) summary
      pfam00375
      Location:29 → 431
      SDF; Sodium:dicarboxylate symporter family

    2. XM_039110462.2 → XP_038966390.1  excitatory amino acid transporter 5 isoform X2

      UniProtKB/TrEMBL
      F2YRM6
      Conserved Domains (1) summary
      pfam00375
      Location:76 → 331
      SDF; Sodium:dicarboxylate symporter family
    Nucleotide Protein Strain
    Heading Accession and Version

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