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    Frmd4a FERM domain containing 4A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307128, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Frmd4aprovided by RGD
    Official Full Name
    FERM domain containing 4Aprovided by RGD
    Primary source
    RGD:1309050
    See related
    EnsemblRapid:ENSRNOG00000018500 AllianceGenome:RGD:1309050
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309050
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in negative regulation of protein secretion and positive regulation of protein secretion. Predicted to act upstream of or within establishment of epithelial cell polarity. Predicted to be located in cytoplasm. Predicted to be active in adherens junction and bicellular tight junction. Orthologous to human FRMD4A (FERM domain containing 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 47.8), Brain (RPKM 42.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Frmd4a in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (78577062..79167924, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (73667787..74258487, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (77642302..77918210, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinases regulatory subunit 2 pseudogene Neighboring gene F-box and leucine-rich repeat protein 14, pseudogene 1 Neighboring gene pre-mRNA processing factor 18 Neighboring gene uncharacterized LOC120097893 Neighboring gene uncharacterized LOC134482746 Neighboring gene uncharacterized LOC134482745 Neighboring gene uncharacterized LOC120097894 Neighboring gene uncharacterized LOC120097896 Neighboring gene uncharacterized LOC134482744 Neighboring gene uncharacterized LOC102554651 Neighboring gene family with sequence similarity 107, member B Neighboring gene uncharacterized LOC108348592

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex. Ikenouchi J, et al. Proc Natl Acad Sci U S A, 2010 Jan 12. PMID 20080746, Free PMC Article
    2. FRMD4A-cytohesin signaling modulates the cellular release of tau. Yan X, et al. J Cell Sci, 2016 May 15. PMID 27044754
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of epithelial cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FERM domain-containing protein 4A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191821.1 → NP_001178750.1  FERM domain-containing protein 4A

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A0G2K2R0, A0A8I6AR03
      Related
      ENSRNOP00000096584.1, ENSRNOT00000104402.2
      Conserved Domains (5) summary
      smart00295
      Location:54 → 254
      B41; Band 4.1 homologues
      cd13191
      Location:250 → 360
      FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
      pfam00373
      Location:140 → 254
      FERM_M; FERM central domain
      pfam09379
      Location:57 → 118
      FERM_N; FERM N-terminal domain
      pfam11819
      Location:417 → 524
      DUF3338; Domain of unknown function (DUF3338)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      78577062..79167924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095788.2 → XP_038951716.1  FERM domain-containing protein 4A isoform X5

      UniProtKB/TrEMBL
      A0A0G2K2R0
      Related
      ENSRNOP00000072339.3, ENSRNOT00000081645.3
      Conserved Domains (4) summary
      smart00295
      Location:21 → 221
      B41; Band 4.1 homologues
      cd13191
      Location:217 → 327
      FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
      cd17200
      Location:18 → 106
      FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
      pfam11819
      Location:356 → 490
      DUF3338; Domain of unknown function (DUF3338)

    2. XM_063276496.1 → XP_063132566.1  FERM domain-containing protein 4A isoform X6

      UniProtKB/TrEMBL
      A0A0G2K2R0, A0A8I5ZZA8
      Related
      ENSRNOP00000106415.1, ENSRNOT00000162805.1

    3. XM_039095786.2 → XP_038951714.1  FERM domain-containing protein 4A isoform X3

      UniProtKB/TrEMBL
      A0A0G2K2R0, A0A8I6B3B1
      Related
      ENSRNOP00000095782.1, ENSRNOT00000096103.2
      Conserved Domains (4) summary
      smart00295
      Location:28 → 228
      B41; Band 4.1 homologues
      cd13191
      Location:224 → 334
      FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
      cd17200
      Location:25 → 113
      FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
      pfam11819
      Location:363 → 497
      DUF3338; Domain of unknown function (DUF3338)

    4. XM_039095784.2 → XP_038951712.1  FERM domain-containing protein 4A isoform X2

      UniProtKB/TrEMBL
      A0A0G2K2R0, A0A8I6APE6
      Related
      ENSRNOP00000095559.1, ENSRNOT00000105615.2
      Conserved Domains (4) summary
      smart00295
      Location:36 → 236
      B41; Band 4.1 homologues
      cd13191
      Location:232 → 342
      FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
      cd17200
      Location:33 → 121
      FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
      pfam11819
      Location:371 → 505
      DUF3338; Domain of unknown function (DUF3338)

    5. XM_039095791.2 → XP_038951719.1  FERM domain-containing protein 4A isoform X7

      UniProtKB/TrEMBL
      A0A0G2K2R0
      Related
      ENSRNOP00000044582.7, ENSRNOT00000045765.7
      Conserved Domains (4) summary
      smart00295
      Location:6 → 206
      B41; Band 4.1 homologues
      cd13191
      Location:202 → 312
      FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
      cd17200
      Location:3 → 91
      FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
      pfam11819
      Location:341 → 475
      DUF3338; Domain of unknown function (DUF3338)

    6. XM_039095789.2 → XP_038951717.1  FERM domain-containing protein 4A isoform X7

      UniProtKB/TrEMBL
      A0A0G2K2R0
      Conserved Domains (4) summary
      smart00295
      Location:6 → 206
      B41; Band 4.1 homologues
      cd13191
      Location:202 → 312
      FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
      cd17200
      Location:3 → 91
      FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
      pfam11819
      Location:341 → 475
      DUF3338; Domain of unknown function (DUF3338)

    7. XM_039095790.2 → XP_038951718.1  FERM domain-containing protein 4A isoform X7

      UniProtKB/TrEMBL
      A0A0G2K2R0
      Conserved Domains (4) summary
      smart00295
      Location:6 → 206
      B41; Band 4.1 homologues
      cd13191
      Location:202 → 312
      FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
      cd17200
      Location:3 → 91
      FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
      pfam11819
      Location:341 → 475
      DUF3338; Domain of unknown function (DUF3338)

    8. XM_039095794.2 → XP_038951722.1  FERM domain-containing protein 4A isoform X8

      UniProtKB/TrEMBL
      A0A8I6GMH6, D3ZU85
      Conserved Domains (2) summary
      pfam11819
      Location:47 → 181
      DUF3338; Domain of unknown function (DUF3338)
      cl17171
      Location:1 → 18
      PH-like; Pleckstrin homology-like domain

    9. XM_039095793.2 → XP_038951721.1  FERM domain-containing protein 4A isoform X8

      UniProtKB/TrEMBL
      A0A8I6GMH6, D3ZU85
      Conserved Domains (2) summary
      pfam11819
      Location:47 → 181
      DUF3338; Domain of unknown function (DUF3338)
      cl17171
      Location:1 → 18
      PH-like; Pleckstrin homology-like domain

    10. XM_039095796.2 → XP_038951724.1  FERM domain-containing protein 4A isoform X9

      UniProtKB/TrEMBL
      D3ZU85
      Conserved Domains (1) summary
      pfam11819
      Location:1 → 104
      DUF3338; Domain of unknown function (DUF3338)

    11. XM_039095787.2 → XP_038951715.1  FERM domain-containing protein 4A isoform X4

      UniProtKB/TrEMBL
      A0A0G2K2R0
      Related
      ENSRNOP00000097387.2, ENSRNOT00000095260.2
      Conserved Domains (4) summary
      smart00295
      Location:36 → 236
      B41; Band 4.1 homologues
      cd13191
      Location:232 → 342
      FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
      cd17200
      Location:33 → 121
      FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
      pfam11819
      Location:371 → 505
      DUF3338; Domain of unknown function (DUF3338)

    12. XM_039095783.2 → XP_038951711.1  FERM domain-containing protein 4A isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2R0
      Conserved Domains (4) summary
      smart00295
      Location:54 → 254
      B41; Band 4.1 homologues
      cd13191
      Location:250 → 360
      FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
      cd17200
      Location:51 → 139
      FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
      pfam11819
      Location:389 → 523
      DUF3338; Domain of unknown function (DUF3338)
    Nucleotide Protein Strain
    Heading Accession and Version

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