Mad2l2 mitotic arrest deficient 2 like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mad2l2provided by RGD
Official Full Name: mitotic arrest deficient 2 like 2provided by RGD
Primary source: RGD:1307499
See related: EnsemblRapid:ENSRNOG00000009134 AllianceGenome:RGD:1307499
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable JUN kinase binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of epithelial to mesenchymal transition; positive regulation of extracellular matrix assembly; and positive regulation of gene expression. Predicted to be located in nucleoplasm and spindle. Predicted to be part of anaphase-promoting complex and zeta DNA polymerase complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group V. Orthologous to human MAD2L2 (mitotic arrest deficient 2 like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 34.9), Heart (RPKM 33.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (163846678..163859851)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (158563545..158576698)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (164943183..164956255)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study demonstrates that AMPK acts as a key regulator of MAD2B expression, suggesting that activation of AMPK signalling might be crucial for the treatment of high glucose-induced neuronal injury
Title: Involvement of AMPK in regulating the degradation of MAD2B under high glucose in neuronal cells.
Skp2, a confirmed APC/C-CDH1 substrate and E-cadherin destroyer, was increased in TGF-beta1-treated proximal tubular epithelial cells, which could be blocked by MAD2B depletion.
Title: MAD2B promotes tubular epithelial-to-mesenchymal transition and renal tubulointerstitial fibrosis via Skp2.
that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression
Title: MAD2B contributes to podocyte injury of diabetic nephropathy via inducing cyclin B1 and Skp2 accumulation.
hyperglycaemia induced neuronal apoptosis through inducing expression of MAD2B, which represents a novel mechanism of diabetic encephalopathy.
Title: Protection of neurons from high glucose-induced injury by deletion of MAD2B.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132073 (e-PCR)
- UniSTS:215356

RH133258 (e-PCR)
- UniSTS:216541

Mad2l2 (e-PCR), detects polymorphism
- UniSTS:546556

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables JUN kinase binding	ISO Inferred from Sequence Orthology more info
enables JUN kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction resulting in transcription	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response, signal transduction resulting in transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in error-prone translesion synthesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by competitive promoter binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of extracellular matrix assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of isotype switching	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	ISO Inferred from Sequence Orthology more info
part_of anaphase-promoting complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info
part_of zeta DNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of zeta DNA polymerase complex	ISO Inferred from Sequence Orthology more info
part_of zeta DNA polymerase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitotic spindle assembly checkpoint protein MAD2B

Names: MAD2 mitotic arrest deficient-like 2; MAD2-like protein 2; mitotic arrest deficient 2-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012106.2 → NP_001012106.1 mitotic spindle assembly checkpoint protein MAD2B isoform 2

See identical proteins and their annotated locations for NP_001012106.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

D3Z8D9

Related

ENSRNOP00000107271.1, ENSRNOT00000123467.1

Conserved Domains (1) summary

pfam02301
Location:18 → 103

HORMA; HORMA domain
NM_001394241.1 → NP_001381170.1 mitotic spindle assembly checkpoint protein MAD2B isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

D3Z8D9, Q5PPH8

Conserved Domains (1) summary

pfam02301
Location:18 → 103

HORMA; HORMA domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

163846678..163859851

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110095.2 → XP_038966023.1 mitotic spindle assembly checkpoint protein MAD2B isoform X2

UniProtKB/Swiss-Prot

D3Z8D9, Q5PPH8

Related

ENSRNOP00000070808.1, ENSRNOT00000083678.3

Conserved Domains (1) summary

pfam02301
Location:18 → 103

HORMA; HORMA domain
XM_063287828.1 → XP_063143898.1 mitotic spindle assembly checkpoint protein MAD2B isoform X2

UniProtKB/Swiss-Prot

D3Z8D9, Q5PPH8
XM_063287824.1 → XP_063143894.1 mitotic spindle assembly checkpoint protein MAD2B isoform X1
XM_063287825.1 → XP_063143895.1 mitotic spindle assembly checkpoint protein MAD2B isoform X1
XM_063287831.1 → XP_063143901.1 mitotic spindle assembly checkpoint protein MAD2B isoform X2

UniProtKB/Swiss-Prot

D3Z8D9, Q5PPH8
XM_063287826.1 → XP_063143896.1 mitotic spindle assembly checkpoint protein MAD2B isoform X1
XM_063287830.1 → XP_063143900.1 mitotic spindle assembly checkpoint protein MAD2B isoform X2

UniProtKB/Swiss-Prot

D3Z8D9, Q5PPH8
XM_063287829.1 → XP_063143899.1 mitotic spindle assembly checkpoint protein MAD2B isoform X2

UniProtKB/Swiss-Prot

D3Z8D9, Q5PPH8
XM_063287827.1 → XP_063143897.1 mitotic spindle assembly checkpoint protein MAD2B isoform X1
XM_063287832.1 → XP_063143902.1 mitotic spindle assembly checkpoint protein MAD2B isoform X3