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    Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116636, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eif4ebp1provided by RGD
    Official Full Name
    eukaryotic translation initiation factor 4E binding protein 1provided by RGD
    Primary source
    RGD:620259
    See related
    EnsemblRapid:ENSRNOG00000081081 AllianceGenome:RGD:620259
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PHAS-I
    Summary
    Enables eukaryotic initiation factor 4E binding activity and protein phosphatase 2A binding activity. Involved in several processes, including cellular response to hypoxia; response to amino acid starvation; and response to ischemia. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic cytosol. Used to study tuberous sclerosis. Orthologous to human EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 227.9), Heart (RPKM 195.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Eif4ebp1 in Genome Data Viewer
    Location:
    16q12.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (71495457..71508845, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (64792595..64805984, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (68954860..68968248, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13A, pseudogene 8 Neighboring gene testis expressed gene 24 like Neighboring gene adrenoceptor beta 3 Neighboring gene glutamic-oxaloacetic transaminase 1-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables eukaryotic initiation factor 4E binding  
    enables eukaryotic initiation factor 4E binding  
    enables eukaryotic initiation factor 4E binding PubMed 
    enables eukaryotic initiation factor 4E binding  
    enables protein phosphatase 2A binding PubMed 
    enables translation initiation factor binding PubMed 
    enables translation initiation factor binding  
    enables translation repressor activity  
    enables translation repressor activity  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle  
    involved_in IRES-dependent translational initiation of linear mRNA  
    involved_in IRES-dependent translational initiation of linear mRNA  
    involved_in TOR signaling  
    involved_in TOR signaling  
    involved_in cellular response to dexamethasone stimulus  
    acts_upstream_of_or_within cellular response to dexamethasone stimulus  
    involved_in cellular response to hypoxia PubMed 
    involved_in insulin receptor signaling pathway  
    acts_upstream_of_or_within insulin receptor signaling pathway  
    involved_in lung development PubMed 
    involved_in negative regulation of protein-containing complex assembly PubMed 
    involved_in negative regulation of translation  
    involved_in negative regulation of translational initiation  
    involved_in negative regulation of translational initiation  
    involved_in negative regulation of translational initiation PubMed 
    acts_upstream_of_or_within negative regulation of translational initiation  
    involved_in negative regulation of translational initiation  
    involved_in positive regulation of mitotic cell cycle  
    involved_in response to amino acid starvation PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to ischemia PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    is_active_in glutamatergic synapse PubMed 
    located_in nucleus  
    is_active_in postsynaptic cytosol PubMed 
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E-binding protein 1
    Names
    4E-BP1
    eIF4E-binding protein 1
    phosphorylated heat- and acid-stable protein regulated by insulin 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053857.2NP_446309.1  eukaryotic translation initiation factor 4E-binding protein 1

      See identical proteins and their annotated locations for NP_446309.1

      Status: VALIDATED

      Source sequence(s)
      AI603218, U05014
      UniProtKB/Swiss-Prot
      Q62622
      UniProtKB/TrEMBL
      A0A8L2Q998
      Related
      ENSRNOP00000087155.1, ENSRNOT00000096679.2
      Conserved Domains (1) summary
      pfam05456
      Location:1117
      eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      71495457..71508845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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