Rps6ka5 ribosomal protein S6 kinase A5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rps6ka5provided by RGD
Official Full Name: ribosomal protein S6 kinase A5provided by RGD
Primary source: RGD:1308336
See related: EnsemblRapid:ENSRNOG00000004362 AllianceGenome:RGD:1308336
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Msk1
Summary: Predicted to enable ATP binding activity and protein kinase activity. Predicted to be involved in several processes, including TORC1 signaling; interleukin-1-mediated signaling pathway; and regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human RPS6KA5 (ribosomal protein S6 kinase A5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 111.2), Brain (RPKM 106.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (125558434..125736576, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (119828823..120006190, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (124557892..124735787, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel Insights into MSK1 Phosphorylation by MRKbeta in Intracerebral Hemorrhage-Induced Neuronal Apoptosis.
Title: Novel Insights into MSK1 Phosphorylation by MRKβ in Intracerebral Hemorrhage-Induced Neuronal Apoptosis.
MSK1 knockdown promotes inflammation and apoptosis and inhibits functional recovery after spinal cord injury.
Title: Inhibition of MSK1 Promotes Inflammation and Apoptosis and Inhibits Functional Recovery After Spinal Cord Injury.
Hypoxic postconditioning induced a significant increase of phosphorylated MSK1 in neurons of hippocampus after transient global cerebral ischemia.
Title: The roles of p38 MAPK/MSK1 signaling pathway in the neuroprotection of hypoxic postconditioning against transient global cerebral ischemia in adult rats.
MSK1 phosphorylation is associated with the mitigation of brain injury and possibly acts as a negative regulator of inflammation.
Title: Phosphorylation of mitogen- and stress-activated protein kinase-1 in astrocytic inflammation: a possible role in inhibiting production of inflammatory cytokines.
data suggested that MSK1 might play important roles in CNS pathophysiology after spinal cord injury
Title: Spatiotemporal patterns and essential role of MSK1 expression after rat spinal cord injury.
MSK1 gene expression in rat brain cortex decreases following traumatic brain injury.
Title: Traumatic brain injury induces a downregulation of MSK1 in rat brain cortex.
the signaling pathways of MAPK, MSK1, and NF-kappaB play important roles in thrombin-induced iNOS expression in alveolar macrophages
Title: Thrombin induces inducible nitric oxide synthase expression via the MAPK, MSK1, and NF-κB signaling pathways in alveolar macrophages.
Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease through its role on chromatin remodeling at the PGC-1-alpha promoter.
Title: Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter.
MSK1 is expressed at highest levels in striatal and olfactory tubercle neurons and to a lesser degree in cerebellar Purkinje cells. MSK1 is also expressed in a subset of astroglia.
Title: Differential localization of MAPK-activated protein kinases RSK1 and MSK1 in mouse brain.
results show for the first time the potential role of JNKs, p38-MAPK and MSK1 in the mechanism of transducing the oxidative stress-signal to HOX-1, possibly promoting cell survival and preserving homeostasis
Title: Involvement of JNKs and p38-MAPK/MSK1 pathways in H2O2-induced upregulation of heme oxygenase-1 mRNA in H9c2 cells.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU049990 (e-PCR)
- UniSTS:146432

RH138282 (e-PCR)
- UniSTS:220369

BE108505 (e-PCR)
- UniSTS:247785

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	ISO Inferred from Sequence Orthology more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	ISO Inferred from Sequence Orthology more info
enables histone H3S28 kinase activity	ISO Inferred from Sequence Orthology more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribosomal protein S6 kinase alpha-5

Names: mitogen and stress-activated protein kinase 1; ribosomal protein S6 kinase, 90kDa, polypeptide 5; ribosomal protein S6 kinase, polypeptide 5

NP_001382521.1

EC 2.7.11.1

XP_006240500.1

EC 2.7.11.1

XP_017449658.1

EC 2.7.11.1

XP_017449660.1

EC 2.7.11.1

XP_038968278.1

EC 2.7.11.1

XP_038968279.1

EC 2.7.11.1

XP_063118042.1

EC 2.7.11.1

XP_063118043.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395592.1 → NP_001382521.1 ribosomal protein S6 kinase alpha-5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6A7D1

Related

ENSRNOP00000063163.2, ENSRNOT00000064716.4

Conserved Domains (2) summary

cd14179
Location:417 → 726

STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1

cl21453
Location:47 → 379

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

125558434..125736576 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240438.5 → XP_006240500.1 ribosomal protein S6 kinase alpha-5 isoform X1

UniProtKB/TrEMBL

A0A8I6A7D1, A0A8I6ABQ6

Related

ENSRNOP00000091483.1, ENSRNOT00000105060.2

Conserved Domains (3) summary

smart00220
Location:405 → 662

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14179
Location:393 → 702

STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1

cl21453
Location:34 → 355

PKc_like; Protein Kinases, catalytic domain
XM_017594169.3 → XP_017449658.1 ribosomal protein S6 kinase alpha-5 isoform X2

UniProtKB/TrEMBL

A0A8I6A7D1
XM_063261972.1 → XP_063118042.1 ribosomal protein S6 kinase alpha-5 isoform X2

UniProtKB/TrEMBL

A0A8I6A7D1
XM_039112350.2 → XP_038968278.1 ribosomal protein S6 kinase alpha-5 isoform X3

Conserved Domains (2) summary

cd14179
Location:199 → 508

STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1

cl21453
Location:1 → 161

PKc_like; Protein Kinases, catalytic domain
XM_063261973.1 → XP_063118043.1 ribosomal protein S6 kinase alpha-5 isoform X3
XM_017594171.3 → XP_017449660.1 ribosomal protein S6 kinase alpha-5 isoform X4
XM_039112351.2 → XP_038968279.1 ribosomal protein S6 kinase alpha-5 isoform X5

UniProtKB/TrEMBL

A6JEH6, D3ZY17

Conserved Domains (1) summary

cl21453
Location:47 → 379

PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108048.1: Suppressed sequence

Description

NM_001108048.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.