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    Ttll9 tubulin tyrosine ligase like 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311548, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ttll9provided by RGD
    Official Full Name
    tubulin tyrosine ligase like 9provided by RGD
    Primary source
    RGD:1359622
    See related
    EnsemblRapid:ENSRNOG00000008596 AllianceGenome:RGD:1359622
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in flagellated sperm motility and microtubule cytoskeleton organization. Predicted to act upstream of or within protein polyglutamylation. Predicted to be located in cytoplasm; microtubule; and motile cilium. Predicted to be active in ciliary basal body. Orthologous to human TTLL9 (tubulin tyrosine ligase like 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 30.1), Lung (RPKM 18.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttll9 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (161876711..161936126)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (141429351..141475965)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (148426008..148485370)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene myosin light chain kinase 2 Neighboring gene forkhead box S1 Neighboring gene dual specificity phosphatase 15 Neighboring gene uncharacterized LOC134486186 Neighboring gene p53 and DNA damage regulated 1 Neighboring gene XK related 7 Neighboring gene uncharacterized LOC108350503

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ttll9-/- mice sperm flagella show shortening of doublet 7, reduction of doublet 5 polyglutamylation and a stall in beating. Konno A, et al. J Cell Sci, 2016 Jul 15. PMID 27257088
    2. A targeted multienzyme mechanism for selective microtubule polyglutamylation. van Dijk J, et al. Mol Cell, 2007 May 11. PMID 17499049
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glutamic acid ligase activity, elongating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin-glutamic acid ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin-glutamic acid ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein polyglutamylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable tubulin polyglutamylase TTLL9
    Names
    tubulin tyrosine ligase-like family, member 9
    tubulin--tyrosine ligase-like protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014051.1 → NP_001014073.1  probable tubulin polyglutamylase TTLL9

      See identical proteins and their annotated locations for NP_001014073.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082105
      UniProtKB/Swiss-Prot
      Q641W7
      UniProtKB/TrEMBL
      A6KHS7, A6KHS8
      Related
      ENSRNOP00000059385.1, ENSRNOT00000064196.4
      Conserved Domains (1) summary
      pfam03133
      Location:74 → 390
      TTL; Tubulin-tyrosine ligase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      161876711..161936126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283827.1 → XP_063139897.1  probable tubulin polyglutamylase TTLL9 isoform X1

      Related
      ENSRNOP00000105884.1, ENSRNOT00000135686.1

    2. XM_063283833.1 → XP_063139903.1  probable tubulin polyglutamylase TTLL9 isoform X5

    3. XM_063283828.1 → XP_063139898.1  probable tubulin polyglutamylase TTLL9 isoform X2

    4. XM_063283834.1 → XP_063139904.1  probable tubulin polyglutamylase TTLL9 isoform X7

    5. XM_063283835.1 → XP_063139905.1  probable tubulin polyglutamylase TTLL9 isoform X8

    6. XM_063283830.1 → XP_063139900.1  probable tubulin polyglutamylase TTLL9 isoform X3

    7. XM_063283831.1 → XP_063139901.1  probable tubulin polyglutamylase TTLL9 isoform X4

    8. XM_063283836.1 → XP_063139906.1  probable tubulin polyglutamylase TTLL9 isoform X9

    9. XM_039105066.2 → XP_038960994.1  probable tubulin polyglutamylase TTLL9 isoform X6

      UniProtKB/TrEMBL
      A6KHS8
      Conserved Domains (1) summary
      cl17255
      Location:90 → 328
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    10. XM_063283829.1 → XP_063139899.1  probable tubulin polyglutamylase TTLL9 isoform X3

    11. XM_006235276.5 → XP_006235338.1  probable tubulin polyglutamylase TTLL9 isoform X4

      UniProtKB/TrEMBL
      A6KHS8
      Conserved Domains (1) summary
      pfam03133
      Location:42 → 358
      TTL; Tubulin-tyrosine ligase family

    RNA

    1. XR_010064633.1 RNA Sequence

    2. XR_010064634.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q641W7.1 GenPept UniProtKB/Swiss-Prot:Q641W7

    Gene LinkOut

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