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    lpgat1 lysophosphatidylglycerol acyltransferase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 561832, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lpgat1provided by ZNC
    Official Full Name
    lysophosphatidylglycerol acyltransferase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2906
    See related
    Ensembl:ENSDARG00000013542 AllianceGenome:ZFIN:ZDB-GENE-030131-2906
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc21c12; fj66b10; wu:fc21c12; wu:fj66b10; zgc:112278; si:dkey-30h14.2
    Summary
    Predicted to enable acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in testis. Orthologous to human LPGAT1 (lysophosphatidylglycerol acyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lpgat1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (13781646..13874344)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (13885547..13978364)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488624 Neighboring gene opsin 8, group member c Neighboring gene NIMA-related kinase 2 Neighboring gene solute carrier family 30 member 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish. Shibata T, et al. Sci Rep, 2022 May 4. PMID 35508627, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112278

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acyl-CoA:lysophosphatidylglycerol acyltransferase 1
    Names
    lysophosphatidylglycerol acyltransferase like
    NP_001025129.1
    XP_005160496.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029958.1 → NP_001025129.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1

      See identical proteins and their annotated locations for NP_001025129.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098616
      UniProtKB/TrEMBL
      A0A8M1N730, Q4KMD5
      Related
      ENSDARP00000098779.1, ENSDART00000115329.3
      Conserved Domains (2) summary
      cd07990
      Location:69 → 286
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:275 → 331
      Acyltransf_C; Acyltransferase C-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      13781646..13874344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160439.5 → XP_005160496.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_005160496.1

      UniProtKB/TrEMBL
      A0A8M1N730, Q4KMD5
      Related
      ENSDARP00000115456.1, ENSDART00000142999.3
      Conserved Domains (2) summary
      cd07990
      Location:69 → 286
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:275 → 331
      Acyltransf_C; Acyltransferase C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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