cpt1a2b carnitine palmitoyltransferase 1A2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cpt1a2bprovided by ZNC
Official Full Name: carnitine palmitoyltransferase 1A2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-155
See related: Ensembl:ENSDARG00000037943 AllianceGenome:ZFIN:ZDB-GENE-050417-155
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cpt1cb; zgc:112484; si:dkey-16p21.4
Summary: Predicted to enable carnitine O-palmitoyltransferase activity. Predicted to be involved in carnitine metabolic process and fatty acid metabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in EVL; periderm; and polster. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency; hereditary spastic paraplegia 73; and lipid metabolism disorder. Orthologous to human CPT1A (carnitine palmitoyltransferase 1A) and CPT1C (carnitine palmitoyltransferase 1C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (32225309..32290053, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (32096679..32158374, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables carnitine O-palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carnitine O-palmitoyltransferase 1, liver isoform; carnitine palmitoyltransferase 1A2b

Names: carnitine palmitoyltransferase 1Cb

XP_005164116.1

EC 2.3.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

32225309..32290053 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005164059.5 → XP_005164116.1 carnitine O-palmitoyltransferase 1, liver isoform

UniProtKB/TrEMBL

A0A8M2BBH8, A0A8M9PFB6, E7EYD4

Related

ENSDARP00000124943.1, ENSDART00000148763.3

Conserved Domains (2) summary

pfam00755
Location:171 → 761

Carn_acyltransf; Choline/Carnitine o-acyltransferase

pfam16484
Location:1 → 46

CPT_N; Carnitine O-palmitoyltransferase N-terminus

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001017668.1: Suppressed sequence

Description

NM_001017668.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from frog (X.tr): cpt1a (GeneID:100135089).