spint2 serine peptidase inhibitor, Kunitz type, 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: spint2provided by ZNC
Official Full Name: serine peptidase inhibitor, Kunitz type, 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-061013-323
See related: Ensembl:ENSDARG00000069476 AllianceGenome:ZFIN:ZDB-GENE-061013-323
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb52h04; fe24a06; wu:fb52h04; wu:fe24a06; zgc:153795
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; ectoderm; oral epithelium; peridermal cell; and polster. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 3. Orthologous to human SPINT2 (serine peptidase inhibitor, Kunitz type 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (20239169..20250516)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (20303437..20314784)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Kunitz-type serine protease inhibitor Spint2 is required for cellular cohesion, coordinated cell migration and cell survival during zebrafish hatching gland development.
Title: The Kunitz-type serine protease inhibitor Spint2 is required for cellular cohesion, coordinated cell migration and cell survival during zebrafish hatching gland development.

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General gene information

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Markers

fb52h04.y1 (e-PCR)
- UniSTS:203295

fj01h10.x1 (e-PCR)
- UniSTS:198266

fe24a06.x1 (e-PCR)
- UniSTS:196303

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kunitz-type protease inhibitor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077250.2 → NP_001070718.2 kunitz-type protease inhibitor 2 precursor

Status: VALIDATED

Source sequence(s)

EB952759, EB963426, EH457273, EH459553

UniProtKB/TrEMBL

A0A8M1NA44, F1QEV7

Related

ENSDARP00000091926.3, ENSDART00000101152.5

Conserved Domains (2) summary

pfam00014
Location:133 → 183

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

cl06508
Location:23 → 100

MANEC; MANEC domain