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    grhprb glyoxylate reductase/hydroxypyruvate reductase b [ Danio rerio (zebrafish) ]

    Gene ID: 402985, updated on 9-Dec-2024

    Summary

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    Official Symbol
    grhprbprovided by ZNC
    Official Full Name
    glyoxylate reductase/hydroxypyruvate reductase bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1847
    See related
    Ensembl:ENSDARG00000019986 AllianceGenome:ZFIN:ZDB-GENE-040426-1847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb80f04; zgc:77636; wu:fb80f04
    Summary
    Predicted to enable glyoxylate reductase (NADPH) activity and hydroxypyruvate reductase (NADH) activity. Predicted to be active in cytosol. Is expressed in hypural; liver; pronephric duct; pronephros; and yolk syncytial layer. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See grhprb in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (19835809..19845539, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (19142872..19152602, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489997 Neighboring gene zinc finger and BTB domain containing 5 Neighboring gene ubiquitin like modifier activating enzyme 6 Neighboring gene amyloid beta (A4) precursor protein-binding, family B, member 2b Neighboring gene uncharacterized LOC137495486

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish models of skeletal dysplasia induced by cholesterol biosynthesis deficiency. Anderson RA, et al. Dis Model Mech, 2020 Jun 24. PMID 32430393, Free PMC Article
    2. Transcriptome kinetics of arsenic-induced adaptive response in zebrafish liver. Lam SH, et al. Physiol Genomics, 2006 Nov 27. PMID 16882884
    3. Global protein expression profiling of zebrafish organs based on in vivo incorporation of stable isotopes. Nolte H, et al. J Proteome Res, 2014 Apr 4. PMID 24611545
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77636

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyoxylate reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxypyruvate reductase (NADH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glyoxylate reductase/hydroxypyruvate reductase
    NP_991248.2
    XP_005168397.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205685.2 → NP_991248.2  glyoxylate reductase/hydroxypyruvate reductase

      Status: VALIDATED

      Source sequence(s)
      BC065431, CR387920
      UniProtKB/TrEMBL
      A0A8M1PK16, F1QYH7, Q6P0V7
      Related
      ENSDARP00000117985.1, ENSDART00000132958.3
      Conserved Domains (2) summary
      COG1052
      Location:30 → 360
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:30 → 352
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      19835809..19845539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168340.5 → XP_005168397.1  glyoxylate reductase/hydroxypyruvate reductase isoform X1

      UniProtKB/TrEMBL
      A0A8M2BFM8, E9QCX2, Q6P0V7
      Related
      ENSDARP00000116020.1, ENSDART00000147502.3
      Conserved Domains (2) summary
      COG1052
      Location:30 → 350
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:30 → 342
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394475.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      17050..26780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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