U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    guk1a guanylate kinase 1a [ Danio rerio (zebrafish) ]

    Gene ID: 415216, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    guk1aprovided by ZNC
    Official Full Name
    guanylate kinase 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040625-130
    See related
    Ensembl:ENSDARG00000030340 AllianceGenome:ZFIN:ZDB-GENE-040625-130
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb295; zgc:86776
    Summary
    Predicted to enable guanylate kinase activity. Predicted to act upstream of or within phosphorylation and purine nucleotide metabolic process. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in cardiovascular system; neural tube; polster; spinal cord; and yolk syncytial layer. Orthologous to human GUK1 (guanylate kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See guk1a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (3026801..3045863, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (3184822..3203884, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene phosphoinositide-3-kinase, regulatory subunit 3a (gamma) Neighboring gene intracisternal A particle-promoted polypeptide Neighboring gene zgc:63882 Neighboring gene ADP-ribosylation factor 1 Neighboring gene wingless-type MMTV integration site family, member 3A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    guanylate kinase
    NP_001002126.2
    NP_001303825.1
    NP_001303828.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002126.2 → NP_001002126.2  guanylate kinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, which results in a different 5'UTR and novel 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AA497237, CABZ01075143, CN504301, EH437861, EH463832
      UniProtKB/TrEMBL
      A0A2R8QGR9, A0A8M1MZZ5
      Related
      ENSDARP00000154253.1, ENSDART00000187575.1
      Conserved Domains (2) summary
      TIGR03263
      Location:14 → 196
      guanyl_kin; guanylate kinase
      pfam00625
      Location:12 → 197
      Guanylate_kin; Guanylate kinase

    2. NM_001316896.1 → NP_001303825.1  guanylate kinase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA497237, CABZ01075143, CN504301, EH437861, EH463832
      UniProtKB/TrEMBL
      A0A2R8RJH6, A0A8M1P7T4
      Related
      ENSDARP00000146525.1, ENSDART00000192642.1
      Conserved Domains (2) summary
      TIGR03263
      Location:17 → 199
      guanyl_kin; guanylate kinase
      pfam00625
      Location:15 → 200
      Guanylate_kin; Guanylate kinase

    3. NM_001316899.1 → NP_001303828.1  guanylate kinase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5'-terminal exon, which results in a different 5' UTR and use of a downstream start codon compared to variant 1. It encodes isoform 3, which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA497237, CABZ01075143, EH437861
      UniProtKB/TrEMBL
      A0A8M1P200, F1R4A7, Q6IQG1
      Related
      ENSDARP00000148571.1, ENSDART00000186795.1
      Conserved Domains (2) summary
      TIGR03263
      Location:5 → 187
      guanyl_kin; guanylate kinase
      pfam00625
      Location:3 → 188
      Guanylate_kin; Guanylate kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      3026801..3045863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools