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    neurod6a neuronal differentiation 6a [ Danio rerio (zebrafish) ]

    Gene ID: 114414, updated on 9-Dec-2024

    Summary

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    Official Symbol
    neurod6aprovided by ZNC
    Official Full Name
    neuronal differentiation 6aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010608-1
    See related
    Ensembl:ENSDARG00000040008 AllianceGenome:ZFIN:ZDB-GENE-010608-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ndr1a; Zath2a; atoh2a; neuroD6-A
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Acts upstream of or within positive regulation of neurogenesis. Predicted to be active in nucleus. Is expressed in dorsal telencephalon and granule cell. Orthologous to human NEUROD6 (neuronal differentiation 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See neurod6a in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (32472155..32474949)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (32557107..32560306)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 17 Neighboring gene ITPR interacting domain containing 1 Neighboring gene eukaryotic translation initiation factor 1B Neighboring gene YME1-like 1a Neighboring gene polyketide synthase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A class of neuroD-related basic helix-loop-helix transcription factors expressed in developing central nervous system in zebrafish. Liao J, et al. DNA Cell Biol, 1999 Apr. PMID 10235116
    2. olig2 is required for zebrafish primary motor neuron and oligodendrocyte development. Park HC, et al. Dev Biol, 2002 Aug 15. PMID 12167410
    3. The functional specificity of NeuroD is defined by a single amino acid residue (N11) in the basic domain. Wang X, et al. FEBS Lett, 2002 Jun 5. PMID 12044886
    4. Neurogenetic asymmetries in the catshark developing habenulae: mechanistic and evolutionary implications. Lagadec R, et al. Sci Rep, 2018 Mar 15. PMID 29545638, Free PMC Article
    5. Identification of an evolutionarily conserved domain in Neurod1 favouring enteroendocrine versus goblet cell fate. Reuter AS, et al. PLoS Genet, 2022 Mar. PMID 35286299, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables E-box binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neurogenic differentiation factor 6-A
    Names
    atonal homolog 2a
    neurogenic differentiation 6a
    protein atonal homolog 2-A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131816.3 → NP_571891.3  neurogenic differentiation factor 6-A

      See identical proteins and their annotated locations for NP_571891.3

      Status: VALIDATED

      Source sequence(s)
      CU138525, EH453807, EH479571
      UniProtKB/Swiss-Prot
      Q6NYU3, Q9W6C6
      UniProtKB/TrEMBL
      A0A8M6Z4N8
      Related
      ENSDARP00000089629.4, ENSDART00000098859.5
      Conserved Domains (2) summary
      cd00083
      Location:87 → 145
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam12533
      Location:147 → 265
      Neuro_bHLH; Neuronal helix-loop-helix transcription factor

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      32472155..32474949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NYU3.1 GenPept UniProtKB/Swiss-Prot:Q6NYU3

    Gene LinkOut

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