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    ap2b1 adaptor related protein complex 2 subunit beta 1 [ Danio rerio (zebrafish) ]

    Gene ID: 334632, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ap2b1provided by ZNC
    Official Full Name
    adaptor related protein complex 2 subunit beta 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6564
    See related
    Ensembl:ENSDARG00000035152 AllianceGenome:ZFIN:ZDB-GENE-030131-6564
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa16e07; zgc:55659; wu:fa16c06; wu:fa16e07; wu:fc18c08
    Summary
    Predicted to enable clathrin binding activity. Predicted to be involved in vesicle-mediated transport. Predicted to act upstream of or within intracellular protein transport. Predicted to be located in endomembrane system and membrane. Predicted to be part of clathrin adaptor complex. Orthologous to human AP2B1 (adaptor related protein complex 2 subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ap2b1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (61657707..61724086)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (60973012..61039365)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene draculin-like, tandem duplicate 1 Neighboring gene draculin Neighboring gene ras-like protein family member 10B Neighboring gene growth arrest specific 2 like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Umasankar PK, et al. Nat Cell Biol, 2012 Apr 8. PMID 22484487, Free PMC Article
    2. A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Ma Z, et al. Sci Rep, 2017 Sep 4. PMID 28871129, Free PMC Article
    3. Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization. Mishima Y, et al. Genes Dev, 2009 Mar 1. PMID 19240126, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AP-2 complex subunit beta
    Names
    adaptor-related protein complex 2, beta 1 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199919.2 → NP_956213.2  AP-2 complex subunit beta

      See identical proteins and their annotated locations for NP_956213.2

      Status: PROVISIONAL

      Source sequence(s)
      BC066566
      UniProtKB/TrEMBL
      A0A0R4IC49, A0A8M1PAE5, B0R152, Q6NYJ9
      Related
      ENSDARP00000132587.2, ENSDART00000171248.2
      Conserved Domains (5) summary
      smart00809
      Location:731 → 831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840 → 950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region
      pfam12717
      Location:99 → 268
      Cnd1; non-SMC mitotic condensation complex subunit 1
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      61657707..61724086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068221111.1 → XP_068077212.1  AP-2 complex subunit beta isoform X1

      Related
      ENSDARP00000050915.4, ENSDART00000050916.6
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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