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    larp6a La ribonucleoprotein 6, translational regulator a [ Danio rerio (zebrafish) ]

    Gene ID: 334471, updated on 4-Jan-2025

    Summary

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    Official Symbol
    larp6aprovided by ZNC
    Official Full Name
    La ribonucleoprotein 6, translational regulator aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6403
    See related
    Ensembl:ENSDARG00000005355 AllianceGenome:ZFIN:ZDB-GENE-030131-6403
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    larp6; fi75f12; zgc:66107; wu:fi75f12
    Summary
    Enables RNA binding activity. Acts upstream of or within somitogenesis. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; mesenchymal cell; post-vent region; segmental plate; and trunk. Orthologous to human LARP6 (La ribonucleoprotein 6, translational regulator). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See larp6a in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (173603..194844)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (284467..305708)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily M, member 7 Neighboring gene leucine-rich repeat-containing protein 49 Neighboring gene TM2 domain containing 3 Neighboring gene threonyl-tRNA synthetase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Recombinant expression and purification of the RNA-binding LARP6 proteins from fish genetic model organisms. Castro JM, et al. Protein Expr Purif, 2017 Jun. PMID 28400296, Free PMC Article
    2. Regulation of muscle differentiation and survival by Acheron. Wang Z, et al. Mech Dev, 2009 Aug-Sep. PMID 19481601
    3. Maternal Larp6 controls oocyte development, chorion formation and elevation. Hau HTA, et al. Development, 2020 Feb 26. PMID 32054660, Free PMC Article
    4. Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair. LeBert D, et al. Elife, 2018 Jan 16. PMID 29336778, Free PMC Article
    5. Ovarian transcriptomic signatures of zebrafish females resistant to different environmental perturbations. Valdivieso A, et al. J Exp Zool B Mol Dev Evol, 2019 May. PMID 30945804

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Larp6 proteins are required for normal oocyte development, chorion formation and egg activation
      Title: Maternal Larp6 controls oocyte development, chorion formation and elevation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    la-related protein 6a
    Names
    La ribonucleoprotein domain family, member 6
    La ribonucleoprotein domain family, member 6a
    ZFOS-508H5.1
    acheron
    achn

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199903.1 → NP_956197.1  la-related protein 6a

      See identical proteins and their annotated locations for NP_956197.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056595
      UniProtKB/TrEMBL
      A0A8M1PDN5, Q6PHD4
      Related
      ENSDARP00000153929.1, ENSDART00000185918.1
      Conserved Domains (3) summary
      cd08033
      Location:79 → 155
      LARP_6; La RNA-binding domain of La-related protein 6
      cd12289
      Location:200 → 284
      RRM_LARP6; RNA recognition motif in La-related protein 6 (LARP6) and similar proteins
      pfam12901
      Location:457 → 472
      SUZ-C; SUZ-C motif

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      173603..194844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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