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    dnpep aspartyl aminopeptidase [ Danio rerio (zebrafish) ]

    Gene ID: 393122, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dnpepprovided by ZNC
    Official Full Name
    aspartyl aminopeptidaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-852
    See related
    Ensembl:ENSDARG00000022599 AllianceGenome:ZFIN:ZDB-GENE-040426-852
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55944
    Summary
    Predicted to enable aminopeptidase activity; metallopeptidase activity; and zinc ion binding activity. Predicted to act upstream of or within proteolysis. Is expressed in female organism. Orthologous to human DNPEP (aspartyl aminopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dnpep in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (13896351..13920334)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (13766867..13790896)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 198ab Neighboring gene uncharacterized LOC110439862 Neighboring gene desmin b Neighboring gene protein tyrosine phosphatase receptor type Nb Neighboring gene microRNA 153b Neighboring gene grancalcin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55944

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aspartyl aminopeptidase
    NP_956447.1
    XP_005165919.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200153.1 → NP_956447.1  aspartyl aminopeptidase

      See identical proteins and their annotated locations for NP_956447.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044551
      UniProtKB/TrEMBL
      A0A8M1PGL2, Q803B5
      Related
      ENSDARP00000006244.7, ENSDART00000009382.9
      Conserved Domains (1) summary
      cd05658
      Location:12 → 457
      M18_DAP; M18 Peptidase Aspartyl aminopeptidase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      13896351..13920334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165862.4 → XP_005165919.1  aspartyl aminopeptidase isoform X1

      UniProtKB/TrEMBL
      A0A8M2BD52, F1QRP8
      Related
      ENSDARP00000110484.1, ENSDART00000122487.4
      Conserved Domains (1) summary
      cd05658
      Location:17 → 462
      M18_DAP; M18 Peptidase Aspartyl aminopeptidase

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394628.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      48816..76119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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