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    gabpb2a GA binding protein transcription factor subunit beta 2a [ Danio rerio (zebrafish) ]

    Gene ID: 554849, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gabpb2aprovided by ZNC
    Official Full Name
    GA binding protein transcription factor subunit beta 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5733
    See related
    Ensembl:ENSDARG00000007943 AllianceGenome:ZFIN:ZDB-GENE-030131-5733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gabpb2; fi15e02; zgc:55805; wu:fi15e02; wu:fi17h09
    Summary
    Predicted to enable transcription cis-regulatory region binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human GABPB2 (GA binding protein transcription factor subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gabpb2a in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (7432710..7441948, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (7513785..7523023, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene RAB25, member RAS oncogene family a Neighboring gene splicing factor 3b, subunit 4 Neighboring gene MLLT11 transcription factor 7 cofactor Neighboring gene MINDY lysine 48 deubiquitinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression profiling and functional characterization of the duplicated Oxr1b gene in zebrafish. Xu H, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2021 Sep. PMID 34111665
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55805, MGC191681

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GA-binding protein subunit beta-2a
    Names
    GA binding protein transcription factor, beta subunit 1, 53kDa
    GA binding protein transcription factor, beta subunit 2a
    GA repeat binding protein, beta 2
    GA repeat binding protein, beta 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099977.2 → NP_001093447.1  GA-binding protein subunit beta-2a

      Status: VALIDATED

      Source sequence(s)
      FP085396
      UniProtKB/TrEMBL
      A0A8M1NDK6, A3KQS6
      Related
      ENSDARP00000027821.5, ENSDART00000003544.7
      Conserved Domains (4) summary
      cd00204
      Location:34 → 156
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:42 → 132
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      7432710..7441948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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