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    pak1ip1 PAK1 interacting protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 336470, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pak1ip1provided by ZNC
    Official Full Name
    PAK1 interacting protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8414
    See related
    Ensembl:ENSDARG00000044488 AllianceGenome:ZFIN:ZDB-GENE-030131-8414
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Gdpd1; fb11d05; zgc:56683; wu:fb11d05
    Summary
    Predicted to enable protein kinase inhibitor activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to act upstream of or within negative regulation of signal transduction and ribosome biogenesis. Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human PAK1IP1 (PAK1 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pak1ip1 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (36158745..36175325, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (36270673..36287228, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 2 Neighboring gene transmembrane protein 14Cb Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 1 Neighboring gene retinoblastoma binding protein 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56683

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    p21-activated protein kinase-interacting protein 1-like
    Names
    glycerophosphodiester phosphodiesterase domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200945.2 → NP_957239.2  p21-activated protein kinase-interacting protein 1-like

      See identical proteins and their annotated locations for NP_957239.2

      Status: PROVISIONAL

      Source sequence(s)
      AY391445
      UniProtKB/Swiss-Prot
      Q6NYY5, Q6TNS2, Q7ZW90
      Related
      ENSDARP00000065337.3, ENSDART00000065338.5
      Conserved Domains (3) summary
      COG2319
      Location:36 → 288
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:46 → 280
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:49 → 85
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      36158745..36175325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217035.1 → XP_068073136.1  p21-activated protein kinase-interacting protein 1-like isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TNS2.1 GenPept UniProtKB/Swiss-Prot:Q6TNS2

    Gene LinkOut

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