myl13 myosin, light chain 13 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: myl13provided by ZNC
Official Full Name: myosin, light chain 13provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1593
See related: Ensembl:ENSDARG00000042245 AllianceGenome:ZFIN:ZDB-GENE-040426-1593
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66286; zgc:77943
Summary: Predicted to enable calcium ion binding activity. Predicted to be part of myosin II complex. Is expressed in adaxial cell; heart; musculature system; and somite. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 8. Orthologous to human MYL3 (myosin light chain 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (2470777..2853529)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (2628878..2639911)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

aa566433 (e-PCR)
- UniSTS:186880

fc28a12.x1 (e-PCR)
- UniSTS:193396

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin, light chain 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200516.1 → NP_956810.1 myosin, light chain 13

See identical proteins and their annotated locations for NP_956810.1

Status: PROVISIONAL

Source sequence(s)

BC055583

UniProtKB/TrEMBL

A0A8N7XJ70, F1QQ39, Q6P6E1, Q7ZUB0

Related

ENSDARP00000061954.5, ENSDART00000061955.6

Conserved Domains (2) summary

PTZ00184
Location:34 → 185

PTZ00184; calmodulin; Provisional

cd00051
Location:123 → 184

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...