rap1aa RAP1A, member of RAS oncogene family a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rap1aaprovided by ZNC
Official Full Name: RAP1A, member of RAS oncogene family aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040625-167
See related: Ensembl:ENSDARG00000012553 AllianceGenome:ZFIN:ZDB-GENE-040625-167
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rap1a; zgc:86676; wu:fc66g06
Summary: Enables MAP kinase kinase activity. Acts upstream of or within chondrocyte intercalation involved in growth plate cartilage morphogenesis and heart development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain. Orthologous to human RAP1A (RAP1A, member of RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (28267546..28274532, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (28248410..28255479, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome.
Title: RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Rap protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Rap protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cartilage morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to cAMP	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chondrocyte intercalation involved in growth plate cartilage morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RAP1A, member of RAS oncogene family a

Names: Rap1b

NP_001002152.1

EC 3.6.5.2

XP_005167080.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002152.1 → NP_001002152.1 RAP1A, member of RAS oncogene family a

See identical proteins and their annotated locations for NP_001002152.1

Status: PROVISIONAL

Source sequence(s)

BC071360

UniProtKB/TrEMBL

A0A8M1N021, Q6IQP4

Related

ENSDARP00000050670.6, ENSDART00000050671.8

Conserved Domains (2) summary

cd04175
Location:3 → 167

Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

smart00010
Location:2 → 168

small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

28267546..28274532 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005167023.4 → XP_005167080.1 RAP1A, member of RAS oncogene family a isoform X1

See identical proteins and their annotated locations for XP_005167080.1

UniProtKB/TrEMBL

A0A8M1N021, Q6IQP4

Related

ENSDARP00000116523.1, ENSDART00000131580.2

Conserved Domains (2) summary

cd04175
Location:3 → 167

Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

smart00010
Location:2 → 168

small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily