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    rgrb retinal G protein coupled receptor b [ Danio rerio (zebrafish) ]

    Gene ID: 554142, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rgrbprovided by ZNC
    Official Full Name
    retinal G protein coupled receptor bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-447
    See related
    AllianceGenome:ZFIN:ZDB-GENE-050522-447
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rgr2; zgc:92677; wu:fb64c10; zgc:109930
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; phototransduction; and visual perception. Predicted to be located in membrane. Is expressed in several structures, including digestive system; endocrine system; optic vesicle; visual system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 44. Orthologous to human RGR (retinal G protein coupled receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See rgrb in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (48965034..48970458, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (48943505..48948929, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene calcium-activated potassium channel subunit alpha-1-like Neighboring gene potassium large conductance calcium-activated channel, subfamily M, alpha member 1b Neighboring gene solute carrier family 18 member 3b Neighboring gene cadherin-related family member 1a Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptional and Behavioral Responses of Zebrafish Larvae to Microcystin-LR Exposure. Tzima E, et al. Int J Mol Sci, 2017 Feb 9. PMID 28208772, Free PMC Article
    2. Silver nanoparticles affect lens rather than retina development in zebrafish embryos. Zhang Y, et al. Ecotoxicol Environ Saf, 2018 Nov 15. PMID 30056342
    3. Zebrafish Circadian Clock Entrainment and the Importance of Broad Spectral Light Sensitivity. Steindal IAF, et al. Front Physiol, 2020. PMID 32922310, Free PMC Article
    4. Analysis of opsin gene family of Crimson snapper (Lutjanus erythropterus). Liang Q, et al. Gene, 2022 Jan 10. PMID 34509581
    5. An extended family of novel vertebrate photopigments is widely expressed and displays a diversity of function. Davies WI, et al. Genome Res, 2015 Nov. PMID 26450929, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled photoreceptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to light stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phototransduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phototransduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    retinal G protein coupled receptor b
    Names
    retinal pigment epithelium retinal G protein receptor-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024436.1 → NP_001019607.1  retinal G protein coupled receptor b

      See identical proteins and their annotated locations for NP_001019607.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095058
      UniProtKB/TrEMBL
      Q504E4, Q6DH22
      Conserved Domains (1) summary
      pfam00001
      Location:33 → 254
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      48965034..48970458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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