arf1 ADP-ribosylation factor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: arf1provided by ZNC
Official Full Name: ADP-ribosylation factor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-010724-5
See related: Ensembl:ENSDARG00000009484 AllianceGenome:ZFIN:ZDB-GENE-010724-5
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb33e02; wu:fb78h01
Summary: Predicted to enable GTP binding activity. Acts upstream of or within semicircular canal development. Predicted to be located in Golgi membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in brain; head; pharyngeal arch 3-7; and semicircular canal. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARF1 (ADP ribosylation factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (3062737..3077027, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (3220758..3235048, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 in mitochondrial function via its association with several mitochondrial proteins.
Title: Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish.

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General gene information

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Markers

fj79g07.y1 (e-PCR)
- UniSTS:199938

fc22c07.x1 (e-PCR)
- UniSTS:193086

fi29f12.x1 (e-PCR)
- UniSTS:197211

fc22c07.x1 (e-PCR)
- UniSTS:187815

fb33e02.x1 (e-PCR)
- UniSTS:190412

fb33e02.x1 (e-PCR)
- UniSTS:190413

fb53f03.y1 (e-PCR)
- UniSTS:190683

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within semicircular canal development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within semicircular canal development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ADP-ribosylation factor 1

NP_958860.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.