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    akr7a3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) [ Danio rerio (zebrafish) ]

    Gene ID: 436642, updated on 9-Dec-2024

    Summary

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    Official Symbol
    akr7a3provided by ZNC
    Official Full Name
    aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-62
    See related
    Ensembl:ENSDARG00000016649 AllianceGenome:ZFIN:ZDB-GENE-040718-62
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92502
    Summary
    Predicted to enable aldo-keto reductase (NADPH) activity. Predicted to be active in cytoplasm. Is expressed in gut; liver; myotome; and optic vesicle. Orthologous to several human genes including AKR7L (aldo-keto reductase family 7 like (gene/pseudogene)) and AKR7A3 (aldo-keto reductase family 7 member A3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See akr7a3 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (41838801..41846060)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (41226571..41233830)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 2a Neighboring gene multiple EGF-like-domains 6b Neighboring gene MRT4 homolog, ribosome maturation factor Neighboring gene intermediate filament family orphan 2b Neighboring gene aldehyde dehydrogenase 4 family, member A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of period genes in teleost fish genomes. Wang H. J Mol Evol, 2008 Jul. PMID 18535754
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    aflatoxin B1 aldehyde reductase member 3
    NP_001002369.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002369.1 → NP_001002369.1  aflatoxin B1 aldehyde reductase member 3

      See identical proteins and their annotated locations for NP_001002369.1

      Status: VALIDATED

      Source sequence(s)
      BC076040
      UniProtKB/TrEMBL
      A0A8M1N0E3, F6NHB2, Q6DHD5
      Related
      ENSDARP00000003850.6, ENSDART00000014871.7
      Conserved Domains (2) summary
      cd06660
      Location:2 → 310
      Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...
      COG0667
      Location:2 → 319
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      41838801..41846060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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