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    hnrnpdl heterogeneous nuclear ribonucleoprotein D-like [ Danio rerio (zebrafish) ]

    Gene ID: 406701, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hnrnpdlprovided by ZNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein D-likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2717
    See related
    Ensembl:ENSDARG00000003429 AllianceGenome:ZFIN:ZDB-GENE-040426-2717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hnrpdl; zgc:66169; wu:fa11d08
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in regulation of gene expression. Predicted to be located in chromatin. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 3. Orthologous to human HNRNPDL (heterogeneous nuclear ribonucleoprotein D like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hnrnpdl in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (5017216..5024520, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (5016912..5024226, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene si:ch73-234b20.5 Neighboring gene heterogeneous nuclear ribonucleoprotein D Neighboring gene enolase-phosphatase 1 Neighboring gene transmembrane protein 150C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A defect in the RNA-processing protein HNRPDL causes limb-girdle muscular dystrophy 1G (LGMD1G). Vieira NM, et al. Hum Mol Genet, 2014 Aug 1. PMID 24647604
    2. Proteomic analysis of methyl parathion-responsive proteins in zebrafish (Danio rerio) brain. Huang QY, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2011 Jan. PMID 20826231
    3. Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Du Z, et al. Biochem Biophys Res Commun, 2016 Jun 24. PMID 27235108
    4. An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. Fouchécourt S, et al. BMC Evol Biol, 2019 Jul 3. PMID 31269894, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein D-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328494.1 → NP_001315423.1  heterogeneous nuclear ribonucleoprotein D-like

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the protein.
      Source sequence(s)
      CR847788, EH541511, EH541767, EH562663, EH585301
      UniProtKB/TrEMBL
      A0A8M9QC13, Q7SXN2
      Related
      ENSDARP00000152490.1, ENSDART00000189017.1
      Conserved Domains (2) summary
      cd12585
      Location:116 → 190
      RRM2_hnRPDL; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and similar proteins
      cd12758
      Location:31 → 106
      RRM1_hnRPDL; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like or hnRNP DL) and similar proteins

    RNA

    1. NR_137312.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CR847788, EH585301

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      5017216..5024520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155542.4 → XP_005155599.1  heterogeneous nuclear ribonucleoprotein D-like isoform X2

      See identical proteins and their annotated locations for XP_005155599.1

      UniProtKB/TrEMBL
      A0A8M9QKN0
      Conserved Domains (2) summary
      cd12585
      Location:116 → 190
      RRM2_hnRPDL; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and similar proteins
      cd12758
      Location:31 → 106
      RRM1_hnRPDL; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like or hnRNP DL) and similar proteins

    2. XM_068223762.1 → XP_068079863.1  heterogeneous nuclear ribonucleoprotein D-like isoform X2

      UniProtKB/TrEMBL
      A0A8M9QKN0

    3. XM_021479149.2 → XP_021334824.1  heterogeneous nuclear ribonucleoprotein D-like isoform X1

      UniProtKB/TrEMBL
      A0A8M9QC13, Q7SXN2
      Conserved Domains (2) summary
      cd12585
      Location:116 → 190
      RRM2_hnRPDL; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and similar proteins
      cd12758
      Location:31 → 106
      RRM1_hnRPDL; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like or hnRNP DL) and similar proteins

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394763.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      71644..79249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395286.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      65127..72685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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