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    epb41l5 erythrocyte membrane protein band 4.1 like 5 [ Danio rerio (zebrafish) ]

    Gene ID: 368449, updated on 9-Dec-2024

    Summary

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    Official Symbol
    epb41l5provided by ZNC
    Official Full Name
    erythrocyte membrane protein band 4.1 like 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-450
    See related
    Ensembl:ENSDARG00000032324 AllianceGenome:ZFIN:ZDB-GENE-030616-450
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dZ104F18.2; dZ104F18.3; si:dz37o5.2; si:dz104f18.2; si:dz104f18.3
    Summary
    Predicted to enable cytoskeletal protein binding activity. Acts upstream of or within several processes, including eye morphogenesis; maintenance of epithelial cell apical/basal polarity; and positive regulation of Notch signaling pathway. Located in bicellular tight junction. Part of protein-containing complex. Is expressed in integument; nervous system; and pronephros. Used to study proteinuria. Orthologous to human EPB41L5 (erythrocyte membrane protein band 4.1 like 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See epb41l5 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (28870697..28939210, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (29059948..29128478, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101884827 Neighboring gene receptor activity modifying protein 1 Neighboring gene uncharacterized LOC137490688 Neighboring gene protein tyrosine phosphatase non-receptor type 4a Neighboring gene transmembrane protein 177

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Sexually dimorphic gene expression in the brains of mature zebrafish. Santos EM, et al. Comp Biochem Physiol A Mol Integr Physiol, 2008 Mar. PMID 18289901
    2. Molecular and cellular determinants of motor asymmetry in zebrafish. Horstick EJ, et al. Nat Commun, 2020 Mar 3. PMID 32127541, Free PMC Article
    3. Zebrafish mosaic eyes is a novel FERM protein required for retinal lamination and retinal pigmented epithelial tight junction formation. Jensen AM, et al. Curr Biol, 2004 Apr 20. PMID 15084287
    4. Organization of the pronephric filtration apparatus in zebrafish requires Nephrin, Podocin and the FERM domain protein Mosaic eyes. Kramer-Zucker AG, et al. Dev Biol, 2005 Sep 15. PMID 16102746, Free PMC Article
    5. Tissue-specific requirements for specific domains in the FERM protein Moe/Epb4.1l5 during early zebrafish development. Christensen AK, et al. BMC Dev Biol, 2008 Jan 11. PMID 18190700, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epb41l5 interacts with Iqcb1 and regulates ciliary function in zebrafish embryos.
      Title: Epb41l5 interacts with Iqcb1 and regulates ciliary function in zebrafish embryos.
    2. Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons.
      Title: Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons.
    3. Data suggest that the Crb/Moe complex and Notch play roles in a positive feedback loop to maintain the apicobasal polarity in neuroepithelial cells.
      Title: Dual roles of Notch in regulation of apically restricted mitosis and apicobasal polarity of neuroepithelial cells.
    4. our data provide further evidence that Moe is a negative regulator of rod outer segment size
      Title: Tissue-specific requirements for specific domains in the FERM protein Moe/Epb4.1l5 during early zebrafish development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1548

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dorsal motor nucleus of vagus nerve development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic retina morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment or maintenance of apical/basal cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment or maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of Notch signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within protein-containing complex localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in bicellular tight junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor inner segment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    band 4.1-like protein 5
    Names
    moe
    mosaic eyes

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200089.2 → NP_956383.1  band 4.1-like protein 5

      See identical proteins and their annotated locations for NP_956383.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066560
      UniProtKB/TrEMBL
      Q6NYK4
      Related
      ENSDARP00000092050.4, ENSDART00000101276.6
      Conserved Domains (5) summary
      smart00295
      Location:44 → 235
      B41; Band 4.1 homologues
      cd13186
      Location:231 → 331
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      cd14473
      Location:135 → 227
      FERM_B-lobe; FERM domain B-lobe
      pfam08736
      Location:344 → 375
      FA; FERM adjacent (FA)
      pfam09379
      Location:47 → 109
      FERM_N; FERM N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      28870697..28939210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223331.1 → XP_068079432.1  band 4.1-like protein 5 isoform X7

    2. XM_068223327.1 → XP_068079428.1  band 4.1-like protein 5 isoform X3

      Related
      ENSDARP00000119020.1, ENSDART00000132878.3

    3. XM_068223330.1 → XP_068079431.1  band 4.1-like protein 5 isoform X6

    4. XM_068223328.1 → XP_068079429.1  band 4.1-like protein 5 isoform X4

    5. XM_068223329.1 → XP_068079430.1  band 4.1-like protein 5 isoform X5

    6. XM_068223326.1 → XP_068079427.1  band 4.1-like protein 5 isoform X2

    7. XM_068223324.1 → XP_068079425.1  band 4.1-like protein 5 isoform X1

      Related
      ENSDARP00000092043.5, ENSDART00000101269.5

    8. XM_068223325.1 → XP_068079426.1  band 4.1-like protein 5 isoform X1

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395284.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      154837..217168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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