fan1 FANCD2 and FANCI associated nuclease 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fan1provided by ZNC
Official Full Name: FANCD2 and FANCI associated nuclease 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6225
See related: Ensembl:ENSDARG00000062269 AllianceGenome:ZFIN:ZDB-GENE-030131-6225
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mtmr15; fi39f01; wu:fd06a07; wu:fi39f01; si:ch211-163b1.2; si:ch211-201b11.2
Summary: Predicted to enable flap-structured DNA binding activity; nuclease activity; and ubiquitin-modified protein reader activity. Predicted to be involved in double-strand break repair via homologous recombination; interstrand cross-link repair; and nucleotide-excision repair. Predicted to act upstream of or within DNA repair. Predicted to be active in nucleus. Is expressed in female organism. Human ortholog(s) of this gene implicated in karyomegalic interstitial nephritis. Orthologous to human FAN1 (FANCD2 and FANCI associated nuclease 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (21688473..21725635, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (21699204..21736569, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fd06a07.x1 (e-PCR)
- UniSTS:204065

fi39f01.x1 (e-PCR)
- UniSTS:197449

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 5'-3' exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-3' exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables 5'-flap endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-flap endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables endodeoxyribonuclease activity, producing 5'-phosphomonoesters	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables flap-structured DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables flap-structured DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on ester bonds	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables phosphodiesterase I activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-modified protein reader activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in interstrand cross-link repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within interstrand cross-link repair	IEA Inferred from Electronic Annotation more info
involved_in interstrand cross-link repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleotide-excision repair	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: fanconi-associated nuclease 1

Names: FANCD2/FANCI-associated nuclease 1; coiled-coil domain-containing protein MTMR15; myotubularin-related protein 15

NP_001038546.2

EC 3.1.4.1

XP_068070907.1

EC 3.1.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.