kif3a kinesin family member 3A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kif3aprovided by ZNC
Official Full Name: kinesin family member 3Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-71
See related: Ensembl:ENSDARG00000087538 AllianceGenome:ZFIN:ZDB-GENE-050417-71
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc55h04; wu:fc55h04; zgc:110284
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within several processes, including cilium assembly; photoreceptor cell maintenance; and photoreceptor cell outer segment organization. Part of kinesin complex. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human KIF3A (kinesin family member 3A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (23970818..23999566)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (23673573..23702321)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

overexpression of full-length rhodopsin or its cytoplasmic tail domain, but not of rhodopsin lacking the cytoplasmic tail, exacerbated rod degeneration in kif3a mutants, implying an important role of the cytoplasmic tail in rod degeneration.
Title: The cytoplasmic tail of rhodopsin triggers rapid rod degeneration in kinesin-2 mutants.
KIF3A plays a conserved role in photoreceptor outer segment formation and intracellular transport.
Title: Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fc55h04 (e-PCR)
- UniSTS:189370

G45881 (e-PCR)
- UniSTS:106683

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde axonal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule-based movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photoreceptor cell outer segment organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kinesin-like protein KIF3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017604.2 → NP_001017604.2 kinesin-like protein KIF3A

Status: VALIDATED

Source sequence(s)

CU179640

UniProtKB/TrEMBL

A0A8M1N5C3, E9QB71

Related

ENSDARP00000107221.2, ENSDART00000123338.4

Conserved Domains (2) summary

cd01371
Location:16 → 348

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

pfam00225
Location:23 → 348

Kinesin; Kinesin motor domain