pak4 p21 protein (Cdc42/Rac)-activated kinase 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pak4provided by ZNC
Official Full Name: p21 protein (Cdc42/Rac)-activated kinase 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-040704-69
See related: Ensembl:ENSDARG00000018110 AllianceGenome:ZFIN:ZDB-GENE-040704-69
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92014; im:5916170; wu:fd12b01
Summary: Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within embryonic morphogenesis and myeloid leukocyte differentiation. Predicted to be active in cytoplasm. Is expressed in post-vent region. Orthologous to human PAK4 (p21 (RAC1) activated kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (25452092..25486421)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (25516827..25551156)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

pak4 is dispensable in zebrafish.
Title: The serine-threonine protein kinase PAK4 is dispensable in zebrafish: identification of a morpholino-generated pseudophenotype.
Zebrafish pak4 is required for primitive myeloid cell development.
Title: Maternal pak4 expression is required for primitive myelopoiesis in zebrafish.

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General gene information

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Markers

fd12b01.x1 (e-PCR)
- UniSTS:195154

G44800 (e-PCR)
- UniSTS:105602

G47731 (e-PCR)
- UniSTS:108502

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to starvation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myeloid leukocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein kinase PAK 4

NP_001002222.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002222.2 → NP_001002222.2 serine/threonine-protein kinase PAK 4

Status: VALIDATED

Source sequence(s)

CU856359, EB915778

UniProtKB/TrEMBL

A0A8M1N060, F1QZR2

Related

ENSDARP00000020114.7, ENSDART00000009545.10

Conserved Domains (3) summary

cd06657
Location:373 → 664

STKc_PAK4; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4

smart00220
Location:399 → 645

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd01093
Location:12 → 46

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...