wls Wnt ligand secretion mediator [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wlsprovided by ZNC
Official Full Name: Wnt ligand secretion mediatorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2161
See related: Ensembl:ENSDARG00000009534 AllianceGenome:ZFIN:ZDB-GENE-040426-2161
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gpr117; gpr177; sb:cb610; zgc:64091; id:ibd2010; wu:fb36d04; wu:fb44d10; wu:fb50c06
Summary: Predicted to enable Wnt-protein binding activity. Acts upstream of or within several processes, including brain development; chondrocyte activation; and skeletal system development. Predicted to be located in Golgi membrane and cytoplasmic vesicle membrane. Predicted to be active in endomembrane system and organelle membrane. Is expressed in several structures, including central nervous system; head; inner ear; midbrain neural keel; and neural tube. Human ortholog(s) of this gene implicated in Zaki syndrome. Orthologous to human WLS (Wnt ligand secretion mediator). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (10342097..10386733, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (10558498..10603149, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the chaperon Wls and its ligands Wnt9a and Wnt5b are expressed in the ectoderm, whereas juxtaposed chondrocytes express Frzb and Gpc4.
Title: Roles of Wnt pathway genes wls, wnt9a, wnt5b, frzb and gpc4 in regulating convergent-extension during zebrafish palate morphogenesis.
disruption of wls resulted in a significant loss of craniofacial bone, whereas lack of gpc4, wnt5b and wnt9a resulted in severely delayed endochondral ossification.
Title: Distinct requirements of wls, wnt9a, wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification.
Homozygous wls mutants show a reduction in two cell populations that contribute to the presumptive dorsal habenulae.
Title: Distinct requirements for Wntless in habenular development.
The relatively ubiquitous expression of GPR177 suggests that this protein may serve to regulate Wnt secretion in a variety of embryonic and adult tissue types.
Title: Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cells.

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General gene information

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Markers

fb36d04.x1 (e-PCR)
- UniSTS:190474

G40046 (e-PCR)
- UniSTS:49466

fb44d10 (e-PCR)
- UniSTS:187213

fb50c06.x1 (e-PCR)
- UniSTS:190633

fb36d04 (e-PCR)
- UniSTS:187110

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Wnt protein secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cartilage morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chondrocyte activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endochondral ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within habenula development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intramembranous ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within midbrain-hindbrain boundary development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within semicircular canal development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in organelle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein wntless homolog

Names: G protein-coupled receptor 177; wntless Wnt ligand secretion mediator; wntless homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.