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    asb2b ankyrin repeat and SOCS box containing 2b [ Danio rerio (zebrafish) ]

    Gene ID: 402848, updated on 9-Dec-2024

    Summary

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    Official Symbol
    asb2bprovided by ZNC
    Official Full Name
    ankyrin repeat and SOCS box containing 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-20
    See related
    Ensembl:ENSDARG00000102490 AllianceGenome:ZFIN:ZDB-GENE-040426-20
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    asb2; zgc:77223
    Summary
    Acts upstream of or within cardiac myofibril assembly. Predicted to be part of ubiquitin ligase complex. Is expressed in adaxial cell; brain; cardiovascular system; musculature system; and somite. Orthologous to human ASB2 (ankyrin repeat and SOCS box containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See asb2b in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (53311303..53323196)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (53223947..53231024)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10b Neighboring gene si:ch1073-416d2.4 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box helicase 24 Neighboring gene exonuclease 3'-5' domain containing 1 Neighboring gene unc-79 homolog, NALCN channel complex subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ASB2 is a novel E3 ligase of SMAD9 required for cardiogenesis. Min KD, et al. Sci Rep, 2021 Nov 29. PMID 34845242, Free PMC Article
    2. Proteolysis regulates cardiomyocyte maturation and tissue integration. Fukuda R, et al. Nat Commun, 2017 Feb 17. PMID 28211472, Free PMC Article
    3. Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing Cardiomyocyte Dedifferentiation and Endocardial Expansion. Fang Y, et al. Front Cell Dev Biol, 2020. PMID 32850848, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac muscle cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cardiac myofibril assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cardiac myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 2b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214725.1 → NP_999890.1  ankyrin repeat and SOCS box protein 2b

      See identical proteins and their annotated locations for NP_999890.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067369
      UniProtKB/TrEMBL
      Q6NWY5
      Related
      ENSDARP00000130867.1, ENSDART00000162239.2
      Conserved Domains (5) summary
      cd00204
      Location:150 → 275
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03587
      Location:499 → 539
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      pfam12796
      Location:226 → 316
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:190 → 242
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:91 → 120
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      53311303..53323196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214354.1 → XP_068070455.1  ankyrin repeat and SOCS box protein 2b isoform X2

    2. XM_068214355.1 → XP_068070456.1  ankyrin repeat and SOCS box protein 2b isoform X2

    3. XM_021467128.2 → XP_021322803.1  ankyrin repeat and SOCS box protein 2b isoform X1

      UniProtKB/TrEMBL
      A0A8M9P8U1
      Conserved Domains (2) summary
      cd00204
      Location:150 → 275
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:155 → 186
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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