cyp17a1 cytochrome P450, family 17, subfamily A, polypeptide 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp17a1provided by ZNC
Official Full Name: cytochrome P450, family 17, subfamily A, polypeptide 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040213-2
See related: Ensembl:ENSDARG00000033566 AllianceGenome:ZFIN:ZDB-GENE-040213-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cyp17; P450c17; zgc:66494; wu:fi13g04; wu:fi17b11; wu:fi31c08; zgc:136516
Summary: Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity and steroid 17-alpha-monooxygenase activity. Acts upstream of or within with a positive effect on female sex determination. Acts upstream of or within with a negative effect on male sex determination. Acts upstream of or within androst-4-ene-3,17-dione biosynthetic process and progesterone metabolic process. Predicted to be located in membrane. Is expressed in brain and endocrine system. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate cancer. Orthologous to human CYP17A1 (cytochrome P450 family 17 subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (28601195..28610965, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (28470745..28480717, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish gonad mutant models reveal neuroendocrine mechanisms of brain sexual dimorphism and male mating behaviors of different brain regions.
Title: Zebrafish gonad mutant models reveal neuroendocrine mechanisms of brain sexual dimorphism and male mating behaviors of different brain regions.
Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is important for male brain sex differentiation.
Title: Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is important for male brain sex differentiation.
A gradually increasing number of spermatozoa and testis hypertrophy from 3 to 6 mpf were observed for testicular development in cytochrome P450 cyp17a1-deficient fish.
Title: Characterization of Sexual Trait Development in cyp17a1-Deficient Zebrafish.
Data show that cytochrome P450 enzymes Cyp17-I, Cyp11c1, Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein Foxl2a were detected both in the testis and ovary.
Title: Localization of steroidogenic enzymes and Foxl2a in the gonads of mature zebrafish (Danio rerio).
In vivo, clotrimazole induced a concentration-dependent increase of cyp17a1 gene expression and Cyp17-I protein synthesis in zebrafish testis.
Title: Characterization of testicular expression of P450 17α-hydroxylase, 17,20-lyase in zebrafish and its perturbation by the pharmaceutical fungicide clotrimazole.
Effects of sexual steroids on the expression of foxl2 in Gobiocypris rarus
Title: Effects of sexual steroids on the expression of foxl2 in Gobiocypris rarus.
the enzyme P450c17 seemed to be expressed in ovary and non-gonadal tissues including the brain, gill, liver and intestine
Title: Cloning of zebrafish ovarian P450c17 (CYP17, 17alpha-hydroxylase/17, 20-lyase) and characterization of its expression in gonadal and extra-gonadal tissues.

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General gene information

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Markers

fi13g04.x1 (e-PCR)
- UniSTS:204459

fi17b11.x1 (e-PCR)
- UniSTS:204486

AW175014 (e-PCR)
- UniSTS:205787

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables steroid 17-alpha-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables steroid 17-alpha-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables steroid 17-alpha-monooxygenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within androst-4-ene-3,17-dione biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within_positive_effect female sex determination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within_positive_effect female sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_negative_effect male sex determination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within_negative_effect male sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in progesterone metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within progesterone metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: steroid 17-alpha-hydroxylase/17,20 lyase

NP_997971.2

EC 1.14.14.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.