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    wrap73 WD repeat containing, antisense to TP73 [ Danio rerio (zebrafish) ]

    Gene ID: 334381, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wrap73provided by ZNC
    Official Full Name
    WD repeat containing, antisense to TP73provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6313
    See related
    Ensembl:ENSDARG00000009557 AllianceGenome:ZFIN:ZDB-GENE-030131-6313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wdr8; fi45a07; zgc:56287; wu:fi45a07
    Summary
    Acts upstream of or within lens development in camera-type eye and retina layer formation. Predicted to be part of MWP complex. Predicted to be active in microtubule organizing center. Is expressed in brain; eye; heart; liver; and spleen. Orthologous to human WRAP73 (WD repeat containing, antisense to TP73). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See wrap73 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (48816082..48847772, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (48827313..48859003, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene NLR family CARD domain-containing protein 3 Neighboring gene tumor protein p63 regulated 1-like Neighboring gene tumor protein p73 Neighboring gene retention in endoplasmic reticulum sorting receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Exome sequencing and functional studies in zebrafish identify WDR8 as the causative gene for isolated Microspherophakia in Indian families. Madhangi M, et al. Hum Mol Genet, 2021 Apr 30. PMID 33693649
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina layer formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MWP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein WRAP73
    Names
    WD repeat domain 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328537.1 → NP_001315466.1  WD repeat-containing protein WRAP73

      Status: VALIDATED

      Source sequence(s)
      BX323556, EH448229
      UniProtKB/TrEMBL
      A0A8M1PAF2, B8A4V4
      Related
      ENSDARP00000106990.2, ENSDART00000122458.4
      Conserved Domains (4) summary
      COG2319
      Location:11 → 364
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:14 → 47
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:89 → 399
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl10017
      Location:4 → 36
      Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      48816082..48847772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199893.1: Suppressed sequence

      Description
      NM_199893.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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